Lower inter-partum interval and unhealthy life-style factors are inversely associated with n-3 essential fatty acids changes during pregnancy: a prospective cohort with Brazilian women

To analyze serum fatty acids concentrations during healthy pregnancy and evaluate whether socioeconomic, demographic, obstetric, nutritional, anthropometric and lifestyle factors are associated with their longitudinal changes. A prospective cohort of 225 pregnant women was followed in the 5th-13th,...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0121151-e0121151
Main Authors: Pinto, Thatiana J P, Farias, Dayana R, Rebelo, Fernanda, Lepsch, Jaqueline, Vaz, Juliana S, Moreira, Júlia D, Cunha, Geraldo M, Kac, Gilberto
Format: Article
Language:English
Subjects:
Alcohol use
Alcoholic beverages
Anthropometry
Birth Intervals
Body mass
Body Mass Index
Body size
Brazil
Chromatography
Chromatography, Gas
Chronic illnesses
Cohort Studies
Demographic variables
Demographics
Demography
Diabetes
Diet
Drinking behavior
Epidemiology
Fatty acids
Fatty Acids, Essential - blood
Female
Fish
Gestation
High-Throughput Screening Assays
Humans
Hypertension
Income
Independent variables
Life Style
Linear Models
Lipids
Liquid chromatography
Maternal & child health
Metabolism
Methylation
Nutrition research
Observatories
Polyunsaturated fatty acids
Pregnancy
Pregnancy - blood
Pregnant women
Prenatal care
Prospective Studies
Public health
Seafood
Seafoods
Social factors
Socio-economic aspects
Socioeconomic Factors
Socioeconomics
Studies
Surveys and Questionnaires
Time Factors
Unsaturated fatty acids
Womens health
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Summary:To analyze serum fatty acids concentrations during healthy pregnancy and evaluate whether socioeconomic, demographic, obstetric, nutritional, anthropometric and lifestyle factors are associated with their longitudinal changes. A prospective cohort of 225 pregnant women was followed in the 5th-13th, 20th-26th and 30th-36th weeks of gestation. Serum samples were collected in each trimester of pregnancy and analyzed to determine the fatty acids composition using a high-throughput robotic direct methylation method coupled with fast gas-liquid chromatography. The independent variables comprised the subjects' socioeconomic and demographic status, obstetric history, early pregnancy body mass index (BMI), dietary and lifestyle parameters. Analyses were performed using linear mixed-effects models. The overall absolute concentrations of fatty acids increased from the 1st to the 2nd trimester and slightly increased from the 2nd to the 3rd trimester. Early pregnancy BMI, inter-partum interval and weekly fish intake were the factors associated with changes in eicosapentaenoic + docosahexaenoic acids (EPA+DHA) and total n-3 polyunsaturated fatty acids (PUFAs). Early pregnancy BMI, age and monthly per-capita income were inversely associated with the changes in the n-6/n-3 ratio. Alcohol consumption was positively associated with the n-6/n-3 ratio. Early pregnancy BMI was positively associated with EPA+DHA and total n-3 PUFAs, while presenting a reduced weekly fish intake and a lower inter-partum interval were associated with lower levels of n-3 PUFAs. A lower per-capita family income and a drinking habit were factors that were positively associated with a higher n-6/n-3 ratio.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0121151