Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. The APPsw/Tg2576 mice exhibit age-related deterioration in memory and learning as well as amyloid-beta (Aβ) accumulation, and this mouse strain is considered an effective model...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0120964
Main Authors: Essa, Musthafa Mohamed, Subash, Selvaraju, Akbar, Mohammed, Al-Adawi, Samir, Guillemin, Gilles J
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Aging
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - analysis
Analysis
Animals
Brain
Brain - metabolism
Cytokines
Cytokines - blood
Diet
Dietary Supplements
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Eotaxin
Female
Ficus - chemistry
Ficus - metabolism
Ficus carica
Fruit - chemistry
Fruit - metabolism
Fruits
Genetic engineering
Inflammation
Interleukin 10
Interleukin 2
Interleukin 3
Interleukin 4
Interleukin 5
Interleukin 6
Interleukin 9
Learning
Lythraceae - chemistry
Lythraceae - metabolism
Medical treatment
Memory
Mice
Mice, Transgenic
Neurodegenerative diseases
Neurological diseases
Nutrition
Phoeniceae - chemistry
Phoeniceae - metabolism
Phoenix dactylifera
Polyphenols
Pomegranates
Punica granatum
Rodents
Senescence
Senile plaques
Transgenic mice
Tumor necrosis factor-α
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Summary:Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. The APPsw/Tg2576 mice exhibit age-related deterioration in memory and learning as well as amyloid-beta (Aβ) accumulation, and this mouse strain is considered an effective model for studying the mechanism of accelerated brain aging and senescence. The present study was aimed to investigate the beneficial effects of dietary supplements pomegranate, figs, or the dates on suppressing inflammatory cytokines in APPsw/Tg2576 mice. Changes in the plasma cytokines and Aβ, ATP, and inflammatory cytokines were investigated in the brain of transgenic mice. Significantly enhanced levels of inflammatory cytokines IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, TNF-α and Eotaxin activity were decreased by administration of the diet supplements containing pomegranates, figs, or dates. In addition, putative delays in the formation of senile plaques, as indicated by a decreasing tendency of brain Aβ1-40 and Aβ1-42 contents, were observed. Thus, novel results mediated by reducing inflammatory cytokines during aging may represent one mechanism by which these supplements exert their beneficial effects against neurodegenerative diseases such as AD.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0120964