CD105 expression on CD34-negative spindle-shaped stromal cells of primary tumor is an unfavorable prognostic marker in early breast cancer patients

Several studies have confirmed that the breast tumor microenvironment drives cancer progression and metastatic development. The aim of our research was to investigate the prognostic significance of the breast tumor microenvironment in untreated early breast cancer patients. Therefore, we analyzed th...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0121421-e0121421
Main Authors: Martinez, Leandro Marcelo, Labovsky, Vivian, Calcagno, María de Luján, Davies, Kevin Mauro, Garcia Rivello, Hernán, Rivello, Hernán Garcia, Bianchi, Maria Silvia, Wernicke, Alejandra, Vallone, Valeria Beatriz Fernández, Fernández Vallone, Valeria Beatriz, Chasseing, Norma Alejandra
Format: Article
Language:English
Subjects:
Actins - metabolism
Adult
Aged
Aged, 80 and over
Analysis
Antigens, CD - metabolism
Antigens, CD34 - metabolism
Biology
Biomarkers, Tumor - metabolism
Bone marrow
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer
CD105 antigen
CD146 Antigen - metabolism
CD34 antigen
Collagen
Councils
Development and progression
Disease-Free Survival
Endoglin
Female
Fibroblasts
Gene Expression Regulation, Neoplastic
Hospitals
Humans
Infiltration
Laboratories
Medicine
Metastases
Metastasis
Middle Aged
Mortality
Neoplasm Metastasis
Patients
Prognosis
Receptors, Cell Surface - metabolism
Recurrence
Retrospective Studies
Stem cells
Stromal cells
Stromal Cells - metabolism
Stromal Cells - pathology
Survival
Tumor Microenvironment
Tumors
Womens health
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Summary:Several studies have confirmed that the breast tumor microenvironment drives cancer progression and metastatic development. The aim of our research was to investigate the prognostic significance of the breast tumor microenvironment in untreated early breast cancer patients. Therefore, we analyzed the association of the expression of α-SMA, FSP, CD105 and CD146 in CD34-negative spindle-shaped stromal cells, not associated with the vasculature, in primary breast tumors with classical prognostic marker levels, metastatic recurrence, local relapse, disease-free survival, metastasis-free survival and the overall survival of patients. In the same way, we evaluated the association of the amount of intra-tumor stroma, fibroblasts, collagen deposition, lymphocytic infiltration and myxoid changes in these samples with the clinical-pathological data previously described. This study is the first to demonstrate the high CD105 expression in this stromal cell type as a possible independent marker of unfavorable prognosis in early breast cancer patients. Our study suggests that this new finding can be useful prognostic marker in the clinical-pathological routine.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0121421