Mitogenomes from The 1000 Genome Project reveal new Near Eastern features in present-day Tuscans

Genetic analyses have recently been carried out on present-day Tuscans (Central Italy) in order to investigate their presumable recent Near East ancestry in connection with the long-standing debate on the origins of the Etruscan civilization. We retrieved mitogenomes and genome-wide SNP data from 11...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0119242-e0119242
Main Authors: Gómez-Carballa, Alberto, Pardo-Seco, Jacobo, Amigo, Jorge, Martinón-Torres, Federico, Salas, Antonio
Format: Article
Language:English
Subjects:
Analysis
Civilization
Data processing
Demographics
Deoxyribonucleic acid
DNA
European Continental Ancestry Group - genetics
Evolution, Molecular
Genetic analysis
Genetics
Genome, Mitochondrial
Genomes
Genomics
Haplotypes
Humans
Italy
Legal medicine
Middle East
Mitochondrial DNA
Phylogeny
Phylogeography
Population
Single-nucleotide polymorphism
Studies
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Summary:Genetic analyses have recently been carried out on present-day Tuscans (Central Italy) in order to investigate their presumable recent Near East ancestry in connection with the long-standing debate on the origins of the Etruscan civilization. We retrieved mitogenomes and genome-wide SNP data from 110 Tuscans analyzed within the context of The 1000 Genome Project. For phylogeographic and evolutionary analysis we made use of a large worldwide database of entire mitogenomes (>26,000) and partial control region sequences (>180,000). Different analyses reveal the presence of typical Near East haplotypes in Tuscans representing isolated members of various mtDNA phylogenetic branches. As a whole, the Near East component in Tuscan mitogenomes can be estimated at about 8%; a proportion that is comparable to previous estimates but significantly lower than admixture estimates obtained from autosomal SNP data (21%). Phylogeographic and evolutionary inter-population comparisons indicate that the main signal of Near Eastern Tuscan mitogenomes comes from Iran. Mitogenomes of recent Near East origin in present-day Tuscans do not show local or regional variation. This points to a demographic scenario that is compatible with a recent arrival of Near Easterners to this region in Italy with no founder events or bottlenecks.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0119242