Manifestations of perihepatic lymph nodes in acute flare of chronic hepatitis B: association with HBeAg status and with HBeAg seroconversion

It has been observed that enlargement of perihepatic lymph nodes may be seen in patients with chronic hepatitis B, particularly during acute flares of CHB. We hypothesized that there may be a correlation between the nodal change patterns in CHB patients with acute flare and HBeAg status. Perihepatic...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-02, Vol.10 (2), p.e0117590-e0117590
Main Authors: Ko, Yen-Ling, Sun, Chi-Shu, Chung, Kun-Ming, Lin, Yu-Min, Feng, I-Che, Sheu, Ming-Jen, Koay, Lok-Beng, Lin, Ching-Yih, Ho, Chung-Han, Kuo, Hsing-Tao
Format: Article
Language:English
Subjects:
Adult
Antigens
Antiviral drugs
Cytokines
Enlargement
Female
Flares
Hepatitis
Hepatitis B
Hepatitis B e antigen
Hepatitis B e Antigens - immunology
Hepatitis B, Chronic - diagnostic imaging
Hepatitis B, Chronic - immunology
Humans
Incidence
Infections
Interferon
Internal medicine
Liver
Lymph nodes
Lymph Nodes - diagnostic imaging
Lymph Nodes - immunology
Lymphatic system
Male
Medicine
Middle Aged
Patients
Pharmacy
Seroconversion
Ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has been observed that enlargement of perihepatic lymph nodes may be seen in patients with chronic hepatitis B, particularly during acute flares of CHB. We hypothesized that there may be a correlation between the nodal change patterns in CHB patients with acute flare and HBeAg status. Perihepatic lymph node sizes of 87 patients with acute flares of CHB were documented, with a median follow up of 43 months. Patients were separated into 3 groups, HBeAg-positive with HBe seroconversion (group 1), HBeAg-positive without HBe seroconversion (group 2), and HBeAg-negative (group 3). Group 1 has the highest incidence of enlarged lymph nodes (92.3%) compared with group 2 (75.8%) and group 3 (46.8%) (p = 0.003). And if nodal width at acute flare was > 8mm and interval change of nodal width was >3mm, the incidence of HBeAg seroconversion will be 75% (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0117590