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Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation
The objective of this study was to formulate and evaluate a unique matrix mixture (nanomiemgel) of nanomicelle and nanoemulsion containing aceclofenac and capsaicin using in vitro and in vivo analyses and to compare it to a marketed formulation (Aceproxyvon). Nanomicelles were prepared using Vitamin...
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| Published in: | PloS one 2014-12, Vol.9 (12), p.e115952-e115952 |
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| container_end_page | e115952 |
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| creator | Somagoni, Jaganmohan Boakye, Cedar H A Godugu, Chandraiah Patel, Apurva R Mendonca Faria, Henrique Antonio Zucolotto, Valtencir Singh, Mandip |
| description | The objective of this study was to formulate and evaluate a unique matrix mixture (nanomiemgel) of nanomicelle and nanoemulsion containing aceclofenac and capsaicin using in vitro and in vivo analyses and to compare it to a marketed formulation (Aceproxyvon).
Nanomicelles were prepared using Vitamin E TPGS by solvent evaporation method and nanoemulsion was prepared by high-pressure homogenization method. In vitro drug release and human skin permeation studies were performed and analyzed using HPLC. The efficiency of nanomiemgel as a delivery system was investigated using an imiquimod-induced psoriatic like plaque model developed in C57BL/6 mice.
Atomic Force Microscopy images of the samples exhibited a globular morphology with an average diameter of 200, 250 and 220 nm for NMI, NEM and NMG, respectively. Nanomiemgel demonstrated a controlled release drug pattern and induced 2.02 and 1.97-fold more permeation of aceclofenac and capsaicin, respectively than Aceproxyvon through dermatomed human skin. Nanomiemgel also showed 2.94 and 2.09-fold greater Cmax of aceclofenac and capsaicin, respectively than Aceproxyvon in skin microdialysis study in rats. The PASI score, ear thickness and spleen weight of the imiquimod-induced psoriatic-like plaque model were significantly (p |
| doi_str_mv | 10.1371/journal.pone.0115952 |
| format | article |
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Nanomicelles were prepared using Vitamin E TPGS by solvent evaporation method and nanoemulsion was prepared by high-pressure homogenization method. In vitro drug release and human skin permeation studies were performed and analyzed using HPLC. The efficiency of nanomiemgel as a delivery system was investigated using an imiquimod-induced psoriatic like plaque model developed in C57BL/6 mice.
Atomic Force Microscopy images of the samples exhibited a globular morphology with an average diameter of 200, 250 and 220 nm for NMI, NEM and NMG, respectively. Nanomiemgel demonstrated a controlled release drug pattern and induced 2.02 and 1.97-fold more permeation of aceclofenac and capsaicin, respectively than Aceproxyvon through dermatomed human skin. Nanomiemgel also showed 2.94 and 2.09-fold greater Cmax of aceclofenac and capsaicin, respectively than Aceproxyvon in skin microdialysis study in rats. The PASI score, ear thickness and spleen weight of the imiquimod-induced psoriatic-like plaque model were significantly (p<0.05) reduced in NMG treated mice compared to free drug, NEM, NMI & Aceproxyvon.
Using a new combination of two different drug delivery systems (NEM+NMI), the absorption of the combined system (NMG) was found to be better than either of the individual drug delivery systems due to the utilization of the maximum possible paths of absorption available for that particular drug.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0115952</identifier><identifier>PMID: 25546392</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Absorption ; Administration, Cutaneous ; Aminoquinolines - pharmacology ; Aminoquinolines - therapeutic use ; Animals ; Arthritis ; Atomic force microscopy ; Biomedical materials ; Capsaicin ; Capsaicin - pharmacology ; Capsaicin - therapeutic use ; Cell Proliferation - drug effects ; Controlled release ; Cytokines ; Diclofenac - analogs & derivatives ; Diclofenac - pharmacology ; Diclofenac - therapeutic use ; Disease Models, Animal ; Drug delivery ; Drug Delivery Systems ; Drug Stability ; Drugs ; Ear ; Emulsions ; Evaporation ; Gels - chemistry ; High-performance liquid chromatography ; House mouse ; Humans ; Imiquimod ; Immunohistochemistry ; In vitro methods and tests ; In Vitro Techniques ; In vivo methods and tests ; Inflammation ; Inflammation - pathology ; Keratinocytes - drug effects ; Keratinocytes - pathology ; Liquid chromatography ; Lung cancer ; Medicine and Health Sciences ; Mice ; Micelles ; Microdialysis ; Microscopy ; Microscopy, Atomic Force ; Nanoemulsions ; Nanoparticles - chemistry ; Narcotics ; New combinations ; Organ Size - drug effects ; Penetration ; Permeability ; Pharmaceutical sciences ; Pharmacy ; Polyethylene glycol ; Polyvinyl alcohol ; Psoriasis ; Psoriasis - drug therapy ; Psoriasis - pathology ; Rats ; Rheology ; Skin ; Skin Absorption - drug effects ; Spleen ; Spleen - drug effects ; Spleen - pathology ; Staphylococcus infections ; Surfactants ; Tocopherol ; Topical application ; Transdermal drug delivery systems ; Vitamin E</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e115952-e115952</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Somagoni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Somagoni et al 2014 Somagoni et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c718t-66d8e1b8fbb35d674910c346ca956ba67caa441782fa27c7c4c8ae11d14b9b1e3</citedby><cites>FETCH-LOGICAL-c718t-66d8e1b8fbb35d674910c346ca956ba67caa441782fa27c7c4c8ae11d14b9b1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1640859670/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1640859670?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25546392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jablonski, Monica M.</contributor><creatorcontrib>Somagoni, Jaganmohan</creatorcontrib><creatorcontrib>Boakye, Cedar H A</creatorcontrib><creatorcontrib>Godugu, Chandraiah</creatorcontrib><creatorcontrib>Patel, Apurva R</creatorcontrib><creatorcontrib>Mendonca Faria, Henrique Antonio</creatorcontrib><creatorcontrib>Zucolotto, Valtencir</creatorcontrib><creatorcontrib>Singh, Mandip</creatorcontrib><title>Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The objective of this study was to formulate and evaluate a unique matrix mixture (nanomiemgel) of nanomicelle and nanoemulsion containing aceclofenac and capsaicin using in vitro and in vivo analyses and to compare it to a marketed formulation (Aceproxyvon).
Nanomicelles were prepared using Vitamin E TPGS by solvent evaporation method and nanoemulsion was prepared by high-pressure homogenization method. In vitro drug release and human skin permeation studies were performed and analyzed using HPLC. The efficiency of nanomiemgel as a delivery system was investigated using an imiquimod-induced psoriatic like plaque model developed in C57BL/6 mice.
Atomic Force Microscopy images of the samples exhibited a globular morphology with an average diameter of 200, 250 and 220 nm for NMI, NEM and NMG, respectively. Nanomiemgel demonstrated a controlled release drug pattern and induced 2.02 and 1.97-fold more permeation of aceclofenac and capsaicin, respectively than Aceproxyvon through dermatomed human skin. Nanomiemgel also showed 2.94 and 2.09-fold greater Cmax of aceclofenac and capsaicin, respectively than Aceproxyvon in skin microdialysis study in rats. The PASI score, ear thickness and spleen weight of the imiquimod-induced psoriatic-like plaque model were significantly (p<0.05) reduced in NMG treated mice compared to free drug, NEM, NMI & Aceproxyvon.
Using a new combination of two different drug delivery systems (NEM+NMI), the absorption of the combined system (NMG) was found to be better than either of the individual drug delivery systems due to the utilization of the maximum possible paths of absorption available for that particular drug.</description><subject>Absorption</subject><subject>Administration, Cutaneous</subject><subject>Aminoquinolines - pharmacology</subject><subject>Aminoquinolines - therapeutic use</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Atomic force microscopy</subject><subject>Biomedical materials</subject><subject>Capsaicin</subject><subject>Capsaicin - pharmacology</subject><subject>Capsaicin - therapeutic use</subject><subject>Cell Proliferation - drug effects</subject><subject>Controlled release</subject><subject>Cytokines</subject><subject>Diclofenac - analogs & derivatives</subject><subject>Diclofenac - pharmacology</subject><subject>Diclofenac - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Drug Stability</subject><subject>Drugs</subject><subject>Ear</subject><subject>Emulsions</subject><subject>Evaporation</subject><subject>Gels - chemistry</subject><subject>High-performance liquid chromatography</subject><subject>House mouse</subject><subject>Humans</subject><subject>Imiquimod</subject><subject>Immunohistochemistry</subject><subject>In vitro methods and tests</subject><subject>In Vitro Techniques</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - pathology</subject><subject>Liquid chromatography</subject><subject>Lung cancer</subject><subject>Medicine and Health Sciences</subject><subject>Mice</subject><subject>Micelles</subject><subject>Microdialysis</subject><subject>Microscopy</subject><subject>Microscopy, Atomic Force</subject><subject>Nanoemulsions</subject><subject>Nanoparticles - chemistry</subject><subject>Narcotics</subject><subject>New combinations</subject><subject>Organ Size - drug effects</subject><subject>Penetration</subject><subject>Permeability</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacy</subject><subject>Polyethylene glycol</subject><subject>Polyvinyl alcohol</subject><subject>Psoriasis</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - pathology</subject><subject>Rats</subject><subject>Rheology</subject><subject>Skin</subject><subject>Skin Absorption - drug effects</subject><subject>Spleen</subject><subject>Spleen - drug effects</subject><subject>Spleen - pathology</subject><subject>Staphylococcus infections</subject><subject>Surfactants</subject><subject>Tocopherol</subject><subject>Topical application</subject><subject>Transdermal drug delivery systems</subject><subject>Vitamin E</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tr3DAQx01padK036C0hkJpD95afsjSpRBCHwuhgb6uYiyNd7XIliPZpvvta-86YV1yKDpIGv3mP9JoJgheknhF0oJ82NneNWBWrW1wFROS8zx5FJwTniYRTeL08cn6LHjm_S6O85RR-jQ4S_I8oylPzoPyGzS21lhv0EQRhI0d0ITK9ZtQodEDun3o977DOqysCzvbagkmhLY146LTtoki3YSD7pwNoVHhYTPYEAcw_QF4HjypwHh8Mc8Xwa_Pn35efY2ub76sry6vI1kQ1kWUKoakZFVZprmiRcZJLNOMSuA5LYEWEiDLSMGSCpJCFjKTDJAQRbKSlwTTi-D1Ubc11os5PV4QmsUs57SIR2J9JJSFnWidrsHthQUtDgbrNgJcp6VBITNAVcWYxIxmZa54hSipVJRQQMnYqPVxjtaXNSqJTefALESXJ43eio0dRJYUrOB8FHg3Czh726PvRK29RGOgQdsf7k0I54xPsd78gz78upnawPgA3VR2jCsnUXE55i1NUpJOYVcPUONQWGs51lKlR_vC4f3CYWQ6_NNtoPderH98_3_25veSfXvCbhFMt_XW9FPJ-CWYHUHprPcOq_skk1hMrXCXDTG1gphbYXR7dfpB9053tZ_-BUGzBSM</recordid><startdate>20141229</startdate><enddate>20141229</enddate><creator>Somagoni, Jaganmohan</creator><creator>Boakye, Cedar H A</creator><creator>Godugu, Chandraiah</creator><creator>Patel, Apurva R</creator><creator>Mendonca Faria, Henrique Antonio</creator><creator>Zucolotto, Valtencir</creator><creator>Singh, Mandip</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141229</creationdate><title>Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation</title><author>Somagoni, Jaganmohan ; Boakye, Cedar H A ; Godugu, Chandraiah ; Patel, Apurva R ; Mendonca Faria, Henrique Antonio ; Zucolotto, Valtencir ; Singh, Mandip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c718t-66d8e1b8fbb35d674910c346ca956ba67caa441782fa27c7c4c8ae11d14b9b1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorption</topic><topic>Administration, Cutaneous</topic><topic>Aminoquinolines - pharmacology</topic><topic>Aminoquinolines - therapeutic use</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Atomic force microscopy</topic><topic>Biomedical materials</topic><topic>Capsaicin</topic><topic>Capsaicin - pharmacology</topic><topic>Capsaicin - therapeutic use</topic><topic>Cell Proliferation - drug effects</topic><topic>Controlled release</topic><topic>Cytokines</topic><topic>Diclofenac - analogs & derivatives</topic><topic>Diclofenac - pharmacology</topic><topic>Diclofenac - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Drug Stability</topic><topic>Drugs</topic><topic>Ear</topic><topic>Emulsions</topic><topic>Evaporation</topic><topic>Gels - chemistry</topic><topic>High-performance liquid chromatography</topic><topic>House mouse</topic><topic>Humans</topic><topic>Imiquimod</topic><topic>Immunohistochemistry</topic><topic>In vitro methods and tests</topic><topic>In Vitro Techniques</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - pathology</topic><topic>Liquid chromatography</topic><topic>Lung cancer</topic><topic>Medicine and Health Sciences</topic><topic>Mice</topic><topic>Micelles</topic><topic>Microdialysis</topic><topic>Microscopy</topic><topic>Microscopy, Atomic Force</topic><topic>Nanoemulsions</topic><topic>Nanoparticles - chemistry</topic><topic>Narcotics</topic><topic>New combinations</topic><topic>Organ Size - drug effects</topic><topic>Penetration</topic><topic>Permeability</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacy</topic><topic>Polyethylene glycol</topic><topic>Polyvinyl alcohol</topic><topic>Psoriasis</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - pathology</topic><topic>Rats</topic><topic>Rheology</topic><topic>Skin</topic><topic>Skin Absorption - drug effects</topic><topic>Spleen</topic><topic>Spleen - drug effects</topic><topic>Spleen - pathology</topic><topic>Staphylococcus infections</topic><topic>Surfactants</topic><topic>Tocopherol</topic><topic>Topical application</topic><topic>Transdermal drug delivery systems</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Somagoni, Jaganmohan</creatorcontrib><creatorcontrib>Boakye, Cedar H A</creatorcontrib><creatorcontrib>Godugu, Chandraiah</creatorcontrib><creatorcontrib>Patel, Apurva R</creatorcontrib><creatorcontrib>Mendonca Faria, Henrique Antonio</creatorcontrib><creatorcontrib>Zucolotto, Valtencir</creatorcontrib><creatorcontrib>Singh, Mandip</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Somagoni, Jaganmohan</au><au>Boakye, Cedar H A</au><au>Godugu, Chandraiah</au><au>Patel, Apurva R</au><au>Mendonca Faria, Henrique Antonio</au><au>Zucolotto, Valtencir</au><au>Singh, Mandip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-29</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e115952</spage><epage>e115952</epage><pages>e115952-e115952</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><notes>Conceived and designed the experiments: MS. Performed the experiments: JS CHAB CG ARP. Analyzed the data: HAMF VZ. Wrote the paper: MS JS CHAB CG ARP HAMF VZ.</notes><abstract>The objective of this study was to formulate and evaluate a unique matrix mixture (nanomiemgel) of nanomicelle and nanoemulsion containing aceclofenac and capsaicin using in vitro and in vivo analyses and to compare it to a marketed formulation (Aceproxyvon).
Nanomicelles were prepared using Vitamin E TPGS by solvent evaporation method and nanoemulsion was prepared by high-pressure homogenization method. In vitro drug release and human skin permeation studies were performed and analyzed using HPLC. The efficiency of nanomiemgel as a delivery system was investigated using an imiquimod-induced psoriatic like plaque model developed in C57BL/6 mice.
Atomic Force Microscopy images of the samples exhibited a globular morphology with an average diameter of 200, 250 and 220 nm for NMI, NEM and NMG, respectively. Nanomiemgel demonstrated a controlled release drug pattern and induced 2.02 and 1.97-fold more permeation of aceclofenac and capsaicin, respectively than Aceproxyvon through dermatomed human skin. Nanomiemgel also showed 2.94 and 2.09-fold greater Cmax of aceclofenac and capsaicin, respectively than Aceproxyvon in skin microdialysis study in rats. The PASI score, ear thickness and spleen weight of the imiquimod-induced psoriatic-like plaque model were significantly (p<0.05) reduced in NMG treated mice compared to free drug, NEM, NMI & Aceproxyvon.
Using a new combination of two different drug delivery systems (NEM+NMI), the absorption of the combined system (NMG) was found to be better than either of the individual drug delivery systems due to the utilization of the maximum possible paths of absorption available for that particular drug.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25546392</pmid><doi>10.1371/journal.pone.0115952</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-12, Vol.9 (12), p.e115952-e115952 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1640859670 |
| source | ProQuest - Publicly Available Content Database; PubMed Central |
| subjects | Absorption Administration, Cutaneous Aminoquinolines - pharmacology Aminoquinolines - therapeutic use Animals Arthritis Atomic force microscopy Biomedical materials Capsaicin Capsaicin - pharmacology Capsaicin - therapeutic use Cell Proliferation - drug effects Controlled release Cytokines Diclofenac - analogs & derivatives Diclofenac - pharmacology Diclofenac - therapeutic use Disease Models, Animal Drug delivery Drug Delivery Systems Drug Stability Drugs Ear Emulsions Evaporation Gels - chemistry High-performance liquid chromatography House mouse Humans Imiquimod Immunohistochemistry In vitro methods and tests In Vitro Techniques In vivo methods and tests Inflammation Inflammation - pathology Keratinocytes - drug effects Keratinocytes - pathology Liquid chromatography Lung cancer Medicine and Health Sciences Mice Micelles Microdialysis Microscopy Microscopy, Atomic Force Nanoemulsions Nanoparticles - chemistry Narcotics New combinations Organ Size - drug effects Penetration Permeability Pharmaceutical sciences Pharmacy Polyethylene glycol Polyvinyl alcohol Psoriasis Psoriasis - drug therapy Psoriasis - pathology Rats Rheology Skin Skin Absorption - drug effects Spleen Spleen - drug effects Spleen - pathology Staphylococcus infections Surfactants Tocopherol Topical application Transdermal drug delivery systems Vitamin E |
| title | Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation |
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