The 5-year onset and regression of diabetic retinopathy in Chinese type 2 diabetes patients

To determine the rate and risk factors of diabetic retinopathy (DR) onset and regression in Chinese type 2 diabetes mellitus patients. This is a 5-year community-based prospective study. The demographic information, systemic examination results and ophthalmological test results of each participant w...

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Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e113359-e113359
Main Authors: Jin, Peiyao, Peng, Jinjuan, Zou, Haidong, Wang, Weiwei, Fu, Jiong, Shen, Binjie, Bai, Xuelin, Xu, Xun, Zhang, Xi
Format: Article
Language:English
Subjects:
Age of Onset
Aged
Aged, 80 and over
Blood
Blood pressure
China - epidemiology
Community health care
Demographics
Development and progression
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetic retinopathy
Diabetic Retinopathy - epidemiology
Diabetic Retinopathy - etiology
Drugs
Female
Follow-Up Studies
Glucose
Glycated Hemoglobin A - analysis
Health services
Hemoglobin
Hospitals
Humans
Hyperglycemia
Hyperglycemia - physiopathology
Hypertension
Hypertension - physiopathology
Incidence
Information systems
Insulin - metabolism
Male
Medicine and Health Sciences
Middle Aged
Patients
Population
Prognosis
Prospective Studies
Regression
Retinopathy
Risk analysis
Risk Factors
Studies
Surgery
Triglycerides
Type 2 diabetes
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Summary:To determine the rate and risk factors of diabetic retinopathy (DR) onset and regression in Chinese type 2 diabetes mellitus patients. This is a 5-year community-based prospective study. The demographic information, systemic examination results and ophthalmological test results of each participant were collected. The study outcomes were DR incidence, defined as the onset of DR in at least one eye, and DR regression, defined as full regression from existing DR to no retinopathy without invasive treatments. The associations between each potential risk factor and the outcomes were studied. In total, 778 participants were enrolled. There were 322 patients without DR at baseline, of which 151 participants developed DR during follow-up (DR incidence rate = 46.89%). Baseline hyperglycemia and high blood pressure were two independent risk factors associated with DR incidence. Among the 456 participants with existing DR at entry, 110 fully recovered after 5 years (DR regression rate = 24.12%). Low baseline glucose and low serum triglyceride were two independent factors associated with DR regression. DR incidence occurred more frequently in patients with hyperglycemia and high blood pressure. DR regression occurred mostly in patients with lower glucose and lower serum triglyceride levels among Chinese type 2 diabetes patients.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0113359