Assessment of toxic effects of the methanol extract of Citrus macroptera Montr. Fruit via biochemical and hematological evaluation in female Sprague-Dawley rats

Citrus macroptera Montr. (C. macroptera) is locally known as Satkara. The fruit of this plant is used as appetite stimulant and in the treatment of fever. This study therefore aimed to evaluate the toxic effects of the fruit extract using some biochemical and hematological parameters in rat model. T...

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Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e111101
Main Authors: Uddin, Nizam, Hasan, Md Rakib, Hasan, Md Mahadi, Hossain, Md Monir, Alam, Md Robiul, Hasan, Mohammad Raquibul, Islam, A F M Mahmudul, Rahman, Tasmina, Rana, Md Sohel
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Alkaline Phosphatase - blood
Animals
Appetite
Biochemistry
Biology and Life Sciences
Blood platelets
Body weight
Body Weight - drug effects
Cardiovascular disease
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Citrus
Citrus - chemistry
Citrus - metabolism
Citrus macroptera
Coronary vessels
Density
Diabetes
Drug dosages
Female
Fever
Fruit - chemistry
Fruit - metabolism
Fruits
Glucose
Heart diseases
Hematology
Hemoglobin
Hemoglobins
Herbal medicine
Inflammation
Kidney - pathology
Laboratories
Lesions
Lipids
Liver - pathology
Lung - pathology
Metabolism
Metabolites
Methanol
Methanol - chemistry
Moisture content
Myocardium - pathology
Nutrition research
Organ Size - drug effects
Organ weight
Organs
Pharmacy
Plant Extracts - chemistry
Plant Extracts - toxicity
Rats
Rats, Sprague-Dawley
Solvents
Toxicity
Triglycerides - blood
Water content
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Summary:Citrus macroptera Montr. (C. macroptera) is locally known as Satkara. The fruit of this plant is used as appetite stimulant and in the treatment of fever. This study therefore aimed to evaluate the toxic effects of the fruit extract using some biochemical and hematological parameters in rat model. The effects of methanol extract of Citrus macroptera Montr. fruit administered at 250, 500 and 1000 mg/kg body weight were investigated on hematological and biochemical parameters in Sprague-Dawley female rats. Moreover, histopathological study was performed to observe the presence of pathological lesions in primary body organs. The extract presented no significant effect on body weight, percent water content, relative organ weight and hematological parameters in rat. Significant decrease from control group was observed in the levels of triglyceride, total cholesterol, low density lipoprotein and very low density lipoprotein; thus leading to significant decrease of cardiac risk ratio, castelli's risk index-2, atherogenic coefficient and atherogenic index of plasma at all doses. 500 mg/kg dose significantly decreased alkaline phosphatase (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0111101