Multidetector computed tomography-based microstructural analysis reveals reduced bone mineral content and trabecular bone changes in the lumbar spine after transarterial chemoembolization therapy for hepatocellular carcinoma

It is well recognized that therapeutic irradiation can result in bone damage. However, long-term bone toxicity associated with computed tomography (CT) performed during interventional angiography has received little attention. The purpose of this study was to determine the prevalence of osteoporosis...

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Bibliographic Details
Published in:PloS one 2014-10, Vol.9 (10), p.e110106
Main Authors: Takasu, Miyuki, Yamagami, Takuji, Nakamura, Yuko, Komoto, Daisuke, Kaichi, Yoko, Tani, Chihiro, Date, Shuji, Kiguchi, Masao, Awai, Kazuo
Format: Article
Language:English
Subjects:
Aged
Angiography
Antineoplastic agents
Arthritis
Biocompatibility
Biology and Life Sciences
Biomedical materials
Bone (long)
Bone (trabecular)
Bone density
Bone Density - drug effects
Bone mineral content
Bone mineral density
Cancellous bone
Cancer therapies
Carcinoma, Hepatocellular - therapy
Care and treatment
CAT scans
Chemoembolization
Chemoembolization, Therapeutic - adverse effects
Computation
Computed tomography
Computer architecture
Correlation
Correlation analysis
Drug dosages
Female
Females
Fractures
Health aspects
Hepatitis
Hepatocellular carcinoma
Humans
Image analysis
Image processing
Irradiation
Liver cancer
Liver Neoplasms - therapy
Long bone
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - drug effects
Lumbar Vertebrae - physiopathology
Male
Males
Mathematical analysis
Medical imaging
Medicine and Health Sciences
Microstructural analysis
Multidetector Computed Tomography
Osteoporosis
Osteoporosis - diagnostic imaging
Osteoporosis - etiology
Osteoporosis - pathology
Osteoporosis - physiopathology
Patients
Radiation
Radiation damage
Radiation dosage
Radiology
Regression analysis
Retrospective Studies
Spine
Spine (lumbar)
Therapy
Thorax
Three dimensional analysis
Toxicity
Veins & arteries
Vertebrae
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Summary:It is well recognized that therapeutic irradiation can result in bone damage. However, long-term bone toxicity associated with computed tomography (CT) performed during interventional angiography has received little attention. The purpose of this study was to determine the prevalence of osteoporosis and trabecular microstructural changes in patients after transarterial chemoembolization (TACE) for hepatocellular carcinoma therapy using an interventional-CT system. Spinal microarchitecture was examined by 64-detector CT in 81 patients who underwent TACE, 35 patients with chronic hepatitis, and 79 controls. For each patient, the volumetric CT dose index (CTDIv) during TACE (CTDIv (TACE)), the dose-length product (DLP) during TACE (DLP (TACE)), and CTDIv and DLP of routine dynamic CT scans (CTDIv (CT) and DLP (CT), respectively), were calculated as the sum since 2008. Using a three dimensional (3D) image analysis system, the tissue bone mineral density (tBMD) and trabecular parameters of the 12th thoracic vertebra were calculated. Using tBMD at a reported cutoff value of 68 mg/cm3, the prevalence of osteoporosis was assessed. The prevalence of osteoporosis was significantly greater in the TACE vs. the control group (39.6% vs. 18.2% for males, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0110106