Importance of fatty acid compositions in patients with peripheral arterial disease

Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI ≤0.90 and/or by angiography. Traditional cardio...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e107003-e107003
Main Authors: Gautam, Milan, Izawa, Atsushi, Shiba, Yuji, Motoki, Hirohiko, Takeuchi, Takahiro, Okada, Ayako, Tomita, Takeshi, Miyashita, Yusuke, Koyama, Jun, Ikeda, Uichi
Format: Article
Language:English
Subjects:
Abnormalities
Aged
Angiography
Ankle
Ankle Brachial Index
Arachidonic acid
Arachidonic Acid - blood
Atherosclerosis
Cardiology
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Case-Control Studies
Comorbidity
Comparative analysis
Coronary artery disease
Coronary heart disease
Diabetes
Disease prevention
Eicosapentaenoic acid
Eicosapentaenoic Acid - blood
Essential fatty acids
Fatty acids
Fatty Acids - analysis
Fatty Acids - blood
Female
gamma-Linolenic Acid - blood
Glomerular filtration rate
Glucose
Glycated Hemoglobin A - analysis
Health risk assessment
Health risks
Heart
Heart diseases
Hemoglobin
Hemoglobins
Humans
Japan - epidemiology
Laboratories
Linolenic acid
Low level
Male
Males
Medicine and Health Sciences
Mortality
Patients
Peripheral Arterial Disease - blood
Peripheral Arterial Disease - epidemiology
Peripheral Arterial Disease - physiopathology
Risk analysis
Risk Factors
Unsaturated fatty acids
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Summary:Importance of fatty acid components and imbalances has emerged in coronary heart disease. In this study, we analyzed fatty acids and ankle-brachial index (ABI) in a Japanese cohort. Peripheral arterial disease (PAD) was diagnosed in 101 patients by ABI ≤0.90 and/or by angiography. Traditional cardiovascular risk factors and components of serum fatty acids were examined in all patients (mean age 73.2±0.9 years; 81 males), and compared with those in 373 age- and sex-matched control subjects with no evidence of PAD. The presence of PAD (mean ABI: 0.71±0.02) was independently associated with low levels of gamma-linolenic acid (GLA) (OR: 0.90; 95% CI: 0.85-0.96; P = 0.002), eicosapentaenoic acid∶arachidonic acid (EPA∶AA) ratio (OR: 0.38; 95% CI: 0.17-0.86; P = 0.021), and estimated glomerular filtration rate (OR: 0.97; 95% CI: 0.96-0.98; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0107003