Antiphospholipid antibodies predict progression of abdominal aortic aneurysms

Antiphospholipid antibodies (aPLs) frequently occur in autoimmune and cardiovascular diseases and correlate with a worse clinical outcome. In the present study, we evaluated the association between antiphospholipid antibodies (aPLs), markers of inflammation, disease progression and the presence of a...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e99302-e99302
Main Authors: Duftner, Christina, Seiler, Rüdiger, Dejaco, Christian, Chemelli-Steingruber, Iris, Schennach, Harald, Klotz, Werner, Rieger, Michael, Herold, Manfred, Falkensammer, Jürgen, Fraedrich, Gustav, Schirmer, Michael
Format: Article
Language:English
Subjects:
Abdomen
Aged
Aged, 80 and over
Aneurysm
Aneurysms
Antibodies
Antibodies, Antiphospholipid - blood
Antiphospholipid antibodies
Aorta
Aortic Aneurysm, Abdominal - blood
Aortic Aneurysm, Abdominal - diagnostic imaging
Aortic aneurysms
Biology and Life Sciences
Biomarkers - blood
Blood clots
Cardiovascular diseases
Case-Control Studies
Computed tomography
Disease
Family medical history
Female
Heart diseases
Humans
Immunoglobulins
Inflammation
Internal medicine
Male
Markers
Medicine
Medicine and Health Sciences
Middle Aged
Pathogenesis
Patients
Regression analysis
Risk analysis
Risk factors
Thrombosis
Tomography
Ultrasonic imaging
Ultrasonography
Ultrasound
Vascular surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antiphospholipid antibodies (aPLs) frequently occur in autoimmune and cardiovascular diseases and correlate with a worse clinical outcome. In the present study, we evaluated the association between antiphospholipid antibodies (aPLs), markers of inflammation, disease progression and the presence of an intra-aneurysmal thrombus in abdominal aortic aneurysm (AAA) patients. APLs ELISAs were performed in frozen serum samples of 96 consecutive AAA patients and 48 healthy controls yielding positive test results in 13 patients (13.5%) and 3 controls (6.3%; n.s.). Nine of the 13 aPL-positive AAA patients underwent a second antibody testing >12 weeks apart revealing a positive result in 6 cases. APL-positive patients had increased levels of inflammatory markers compared to aPL-negative patients. Disease progression was defined as an increase of the AAA diameter >0.5 cm/year measured by sonography. Follow-up was performed in 69 patients identifying 41 (59.4%) patients with progressive disease. Performing multipredictor logistic regression analysis adjusting for classical AAA risk factors as confounders, the presence of aPLs at baseline revealed an odds ratio of 9.4 (95% CI 1.0-86.8, p = 0.049) to predict AAA progression. Fifty-five patients underwent a computed tomography in addition to ultrasound assessment indicating intra-aneurysmal thrombus formation in 82.3%. Median thrombus volume was 46.7 cm3 (1.9-377.5). AAA diameter correlated with the size of the intra-aneurysmal thrombus (corrcoeff = 0.721, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0099302