Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer

The RUNX1 transcription factor is widely recognised for its tumour suppressor effects in leukaemia. Recently a putative link to breast cancer has started to emerge, however the function of RUNX1 in breast cancer is still unknown. To investigate if RUNX1 expression was important to clinical outcome i...

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Bibliographic Details

Published in:	PloS one 2014-06, Vol.9 (6), p.e100759-e100759
Main Authors:	Ferrari, Nicola, Mohammed, Zahra M A, Nixon, Colin, Mason, Susan M, Mallon, Elizabeth, McMillan, Donald C, Morris, Joanna S, Cameron, Ewan R, Edwards, Joanne, Blyth, Karen
Format:	Article
Language:	eng
Subjects:	Analysis Bioindicators Biology and Life Sciences Biomarkers Breast cancer Cancer Cancer therapies CD4 antigen CD8 antigen Cell Line, Tumor Chemotherapy Core Binding Factor Alpha 2 Subunit - metabolism DNA microarrays Epidermal growth factor ErbB-2 protein Estrogen Estrogens Female Gene Expression Regulation, Neoplastic Genes Humans Identification Immunohistochemistry Invasiveness Leukemia Life sciences Macrophages Medical prognosis Medical research Medicine and Health Sciences Middle Aged Multivariate analysis Pathology Patients Progesterone Prognosis Receptors, Estrogen - metabolism Regression analysis Runx1 protein Studies Surgery Survival Triple Negative Breast Neoplasms - diagnosis Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumors Veterinary colleges Veterinary medicine
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