Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use

The soluble urokinase plasminogen activator receptor (suPAR) has been recently recognized as a potential biological marker of various disease states, but the impact of a major surgical intervention on the suPAR level has not yet been established. The aim of our study was to investigate if the induct...

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Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e98923-e98923
Main Authors: Gozdzik, Waldemar, Adamik, Barbara, Gozdzik, Anna, Rachwalik, Maciej, Kustrzycki, Wojciech, Kübler, Andrzej
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesiology
Atherosclerosis
Bacterial infections
Bioindicators
Biomarkers
Biomarkers - blood
Biomarkers - chemistry
Blood
Calcium-binding protein
Cardiac patients
Cardiopulmonary Bypass - adverse effects
Cardiovascular disease
Coronary artery
Coronary artery bypass
Coronary Artery Bypass - adverse effects
Coronary vessels
Cytokines
Diabetes
Elective Surgical Procedures - adverse effects
Enzymes
Female
Heart attacks
Heart surgery
Hospital patients
Hospitals
Humans
Inflammation
Interleukin 6
Interleukin 8
Ischemia
Male
Medicine and Health Sciences
Middle Aged
Mortality
Neutrophils
Patients
Plasma levels
Postoperative Complications - blood
Postoperative Complications - etiology
Proteins
Receptors, Urokinase Plasminogen Activator - blood
Receptors, Urokinase Plasminogen Activator - chemistry
Solubility
Statistical analysis
Surgery
Trauma
Troponin
Troponin I
Tumor necrosis factor-TNF
Tumor necrosis factor-α
U-Plasminogen activator
Urokinase
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Summary:The soluble urokinase plasminogen activator receptor (suPAR) has been recently recognized as a potential biological marker of various disease states, but the impact of a major surgical intervention on the suPAR level has not yet been established. The aim of our study was to investigate if the induction of a systemic inflammatory reaction in response to cardiopulmonary bypass would be accompanied by an increase in the plasma suPAR level. Patients undergoing coronary artery bypass grafting under cardiopulmonary bypass (CPB) were added. Based on the baseline suPAR level, patients were divided into group 1 (suPAR within normal range) or group 2 (suPAR above range). Blood was collected before the induction of anesthesia and 6 and 24 hours after surgery. Plasma suPAR, IL-6, IL-8, TNF-α, troponin I, NT-proBNP, and NGAL were quantified to assess the impact of surgical trauma on these markers. The baseline suPAR level was within the normal range in 31 patients (3.3 ng/mL), and elevated in 29 (5.1 ng/mL) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0098923