Limited evolution of inferred HIV-1 tropism while viremia is undetectable during standard HAART therapy

HIV patients on suppressive antiretroviral therapy have undetectable viremia making it impossible to screen plasma HIV tropism if regimen change is required during suppression. We investigated the prevalence and predictors of tropism switch from CCR5-using ("R5") to non-CCR5-using ("n...

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Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e99000
Main Authors: Lee, Guinevere Q, Dong, Winnie, Mo, Theresa, Knapp, David J H F, Brumme, Chanson J, Woods, Conan K, Kanters, Steve, Yip, Benita, Harrigan, P Richard
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Base Sequence
Biological products industry
Biology and Life Sciences
Care and treatment
CCR5 protein
CD4 antigen
Comparative analysis
Evolution, Molecular
Female
Highly active antiretroviral therapy
HIV
HIV infections
HIV tests
HIV-1 - drug effects
HIV-1 - genetics
HIV-1 - physiology
Human immunodeficiency virus
Humans
Male
Medicine and Health Sciences
Middle Aged
Patients
Selection, Genetic - drug effects
Switches
Therapy
Tropism
Viral Tropism - drug effects
Viremia
Viremia - diagnosis
Viremia - drug therapy
Viremia - virology
Viruses
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Summary:HIV patients on suppressive antiretroviral therapy have undetectable viremia making it impossible to screen plasma HIV tropism if regimen change is required during suppression. We investigated the prevalence and predictors of tropism switch from CCR5-using ("R5") to non-CCR5-using ("non-R5") before and after viral suppression in the initially therapy-naïve HOMER cohort from British Columbia, Canada. We compared pre-therapy and post-suppression viral genotypic tropism in patients who initiated on PI/NNRTI-based antiretroviral regimens between 1996-1999 (n = 462). Virologic suppression was defined as having two consecutive viral loads of
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0099000