Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis: a birth cohort study (COCOA)

Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospe...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e96603
Main Authors: Lee, So-Yeon, Yu, Jinho, Ahn, Kang-Mo, Kim, Kyung Won, Shin, Youn Ho, Lee, Kyung-Shin, Hong, Seo Ah, Jung, Young-Ho, Lee, Eun, Yang, Song-I, Seo, Ju-Hee, Kwon, Ji-Won, Kim, Byoung-Ju, Kim, Hyo-Bin, Kim, Woo-Kyung, Song, Dae Jin, Jang, Gwang Cheon, Shim, Jung Yeon, Lee, Soo-Young, Kwon, Ja-Young, Choi, Suk-Joo, Lee, Kyung-Ju, Park, Hee Jin, Won, Hye-Sung, Yoo, Ho-Sung, Kang, Mi-Jin, Kim, Hyung-Young, Hong, Soo-Jong
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
Analysis
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Antibiotics
Asthma
Atopic dermatitis
Biology and Life Sciences
CD14 antigen
Cesarean Section
Children
Cocoa
Cohort analysis
Cord blood
Cytokines
Deoxyribonucleic acid
Dermatitis
Dermatitis, Atopic - chemically induced
Dermatitis, Atopic - genetics
DNA
Eczema
Exposure
Female
Food allergies
Gene polymorphism
Gene-Environment Interaction
Genetic aspects
Genetic Association Studies
Genetic Predisposition to Disease
Genotypes
Gynecology
Health risks
Hospitals
Humans
Immune system
Infant
Infants
Interleukin
Interleukin 13
Interleukin-13 - genetics
Interleukins
Intestinal microflora
Life sciences
Lipopolysaccharide Receptors - genetics
Male
Medicine
Medicine and Health Sciences
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Obstetrics
Pediatrics
Physicians
Polymorphism
Polymorphism, Single Nucleotide
Pregnancy
Pregnant women
Prenatal experience
Prenatal exposure
Prenatal Exposure Delayed Effects - chemically induced
Prenatal Exposure Delayed Effects - genetics
Research and Analysis Methods
Risk
Risk analysis
Risk factors
Signal transduction
Studies
Tumor necrosis factor-TNF
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Summary:Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19-27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0096603