Determining prenatal, early childhood and cumulative long-term lead exposure using micro-spatial deciduous dentine levels

The aim of this study was to assess the validity of micro-spatial dentine lead (Pb) levels as a biomarker for accurately estimating exposure timing over the prenatal and early childhood periods and long-term cumulative exposure to Pb. In a prospective pregnancy cohort sub-sample of 85 subjects, we c...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e97805
Main Authors: Arora, Manish, Austin, Christine, Sarrafpour, Babak, Hernández-Ávila, Mauricio, Hu, Howard, Wright, Robert O, Tellez-Rojo, Martha Maria
Format: Article
Language:English
Subjects:
Ablation
Biology and Life Sciences
Biomarkers
Blood
Blood levels
Calcium isotopes
Child, Preschool
Children
Cities
Cord blood
Dentin - chemistry
Enamel
Environmental Exposure - analysis
Environmental Monitoring - methods
Environmental Monitoring - statistics & numerical data
Environmental Pollutants - analysis
Exposure
Female
Humans
Inductively coupled plasma
Inductively coupled plasma mass spectrometry
Infant
Infant, Newborn
Laser ablation
Lead
Lead - analysis
Lead - blood
Lead content
Lead isotopes
Lead poisoning
Mass Spectrometry
Mass spectroscopy
Maternal-Fetal Exchange
Medicine and Health Sciences
Mexico
Pregnancy
Pregnant women
Prenatal experience
Preventive medicine
Statistics, Nonparametric
Teeth
Tibia
Tooth, Deciduous - chemistry
Umbilical cord
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Summary:The aim of this study was to assess the validity of micro-spatial dentine lead (Pb) levels as a biomarker for accurately estimating exposure timing over the prenatal and early childhood periods and long-term cumulative exposure to Pb. In a prospective pregnancy cohort sub-sample of 85 subjects, we compared dentine Pb levels measured using laser ablation-inductively coupled plasma mass spectrometry with Pb concentrations in maternal blood collected in the second and third trimesters, maternal bone, umbilical cord blood, and childhood serial blood samples collected from the ages of 3 months to ≥6 years. We found that Pb levels (as 208Pb:43Ca) in dentine formed at birth were significantly associated with cord blood Pb (Spearman ρ = 0.69; n = 27; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0097805