Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts

Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest. We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in A...

Full description

Saved in:

Bibliographic Details
Published in:	PLoS medicine 2014-04, Vol.11 (4), p.e1001631
Main Authors:	Zheng, Wei, McLerran, Dale F, Rolland, Betsy A, Fu, Zhenming, Boffetta, Paolo, He, Jiang, Gupta, Prakash Chandra, Ramadas, Kunnambath, Tsugane, Shoichiro, Irie, Fujiko, Tamakoshi, Akiko, Gao, Yu-Tang, Koh, Woon-Puay, Shu, Xiao-Ou, Ozasa, Kotaro, Nishino, Yoshikazu, Tsuji, Ichiro, Tanaka, Hideo, Chen, Chien-Jen, Yuan, Jian-Min, Ahn, Yoon-Ok, Yoo, Keun-Young, Ahsan, Habibul, Pan, Wen-Harn, Qiao, You-Lin, Gu, Dongfeng, Pednekar, Mangesh Suryakant, Sauvaget, Catherine, Sawada, Norie, Sairenchi, Toshimi, Yang, Gong, Wang, Renwei, Xiang, Yong-Bing, Ohishi, Waka, Kakizaki, Masako, Watanabe, Takashi, Oze, Isao, You, San-Lin, Sugawara, Yumi, Butler, Lesley M, Kim, Dong-Hyun, Park, Sue K, Parvez, Faruque, Chuang, Shao-Yuan, Fan, Jin-Hu, Shen, Chen-Yang, Chen, Yu, Grant, Eric J, Lee, Jung Eun, Sinha, Rashmi, Matsuo, Keitaro, Thornquist, Mark, Inoue, Manami, Feng, Ziding, Kang, Daehee, Potter, John D
Format:	Article
Language:	eng
Subjects:	60 APPLIED LIFE SCIENCES Adult Asia Asia - epidemiology cancer risk factors Cardiovascular disease Cardiovascular Diseases - economics Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality china Confidence intervals Cost of Illness Distribution Female Health aspects Health risk assessment Humans Life Sciences lung and intrathoracic tumors Lung cancer Male Medical research Medicine and Health Sciences Medicine, Experimental Men Middle Aged Mortality Neoplasms - economics Neoplasms - epidemiology Neoplasms - etiology Neoplasms - mortality Population Prevalence Prevalence studies (Epidemiology) Respiratory Tract Diseases - economics Respiratory Tract Diseases - epidemiology Respiratory Tract Diseases - etiology Respiratory Tract Diseases - mortality Risk Risk Factors Santé publique et épidémiologie Smoking Smoking - economics Smoking - epidemiology Smoking - mortality smoking habits smoking related disorders South Korea Studies tobacco control Womens health
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest. We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We then estimated smoking-related deaths among adults aged ≥45 y in 2004 in Bangladesh, India, mainland China, Japan, Republic of Korea, Singapore, and Taiwan-accounting for ∼71% of Asia's total population. An approximately 1.44-fold (95% CI = 1.37-1.51) and 1.48-fold (1.38-1.58) elevated risk of death from any cause was found in male and female ever-smokers, respectively. In 2004, active tobacco smoking accounted for approximately 15.8% (95% CI = 14.3%-17.2%) and 3.3% (2.6%-4.0%) of deaths, respectively, in men and women aged ≥45 y in the seven countries/regions combined, with a total number of estimated deaths of ∼1,575,500 (95% CI = 1,398,000-1,744,700). Among men, approximately 11.4%, 30.5%, and 19.8% of deaths due to cardiovascular diseases, cancer, and respiratory diseases, respectively, were attributable to tobacco smoking. Corresponding proportions for East Asian women were 3.7%, 4.6%, and 1.7%, respectively. The strongest association with tobacco smoking was found for lung cancer: a 3- to 4-fold elevated risk, accounting for 60.5% and 16.7% of lung cancer deaths, respectively, in Asian men and East Asian women aged ≥45 y. Tobacco smoking is associated with a substantially elevated risk of mortality, accounting for approximately 2 million deaths in adults aged ≥45 y throughout Asia in 2004. It is likely that smoking-related deaths in Asia will continue to rise over the next few decades if no effective smoking control programs are implemented. Please see later in the article for the Editors' Summary.
ISSN:	1549-1676 1549-1277 1549-1676