Patterns of transmitted HIV drug resistance in Europe vary by risk group

In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. HIV-1 patients newly diagnosed in 27 countries from 2002 through...

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Bibliographic Details
Published in:PloS one 2014-04, Vol.9 (4), p.e94495
Main Authors: Frentz, Dineke, van de Vijver, David, Abecasis, Ana, Albert, Jan, Hamouda, Osamah, Jørgensen, Louise, Kücherer, Claudia, Struck, Daniel, Schmit, Jean-Claude, Vercauteren, Jurgen, Asjö, Birgitta, Balotta, Claudia, Bergin, Colm, Beshkov, Danail, Camacho, Ricardo, Clotet, Bonaventura, Griskevicius, Algirdas, Grossman, Zehava, Horban, Andrzej, Kolupajeva, Tatjana, Korn, Klaus, Kostrikis, Leondios, Linka, Kirsi Liitsola Marek, Nielsen, Claus, Otelea, Dan, Paraskevis, Dimitrios, Paredes, Roger, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Sönnerborg, Anders, Stanekova, Danica, Stanojevic, Maja, Vandamme, Anne-Mieke, Boucher, Charles, Wensing, Annemarie
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Analysis
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
Antiviral agents
Biology and life sciences
Disease prevention
Disease transmission
DNA polymerases
Drug abuse
Drug resistance
Drug Resistance, Viral
Drug therapy
Drugs
Europe - epidemiology
Female
Geographical distribution
Health aspects
Health risks
Health surveillance
Heterosexuality - statistics & numerical data
HIV
HIV infection
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - drug effects
Homosexuality, Male - statistics & numerical data
Hospitals
Human immunodeficiency virus
Humans
Immunology
Infectious diseases
Laboratories
Logistic Models
Male
Medicin och hälsovetenskap
Medicine
Medicine and health sciences
Mens health
Middle Aged
Moniz, Egas
Mutation
Nucleoside reverse transcriptase inhibitors
Nucleosides
Parasitic diseases
Patients
Protease inhibitors
Protease Inhibitors - therapeutic use
Proteinase inhibitors
Public health
Regression analysis
Reverse Transcriptase Inhibitors - therapeutic use
Risk
Risk-Taking
RNA-directed DNA polymerase
Sexual Behavior - statistics & numerical data
Sexually transmitted diseases
STD
Substance Abuse, Intravenous - epidemiology
Substance Abuse, Intravenous - virology
Therapy
Trends
Virology
Viruses
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Summary:In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0094495