Novel coronavirus and astrovirus in Delaware Bay shorebirds

Wild birds are an important but to some extent under-studied reservoir for emerging pathogens. We used unbiased sequencing methods for virus discovery in shorebird samples from the Delaware Bay, USA; an important feeding ground for thousands of migratory birds. Analysis of shorebird fecal samples in...

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Bibliographic Details
Published in:PloS one 2014-04, Vol.9 (4), p.e93395-e93395
Main Authors: Honkavuori, Kirsi S, Briese, Thomas, Krauss, Scott, Sanchez, Maria D, Jain, Komal, Hutchison, Stephen K, Webster, Robert G, Lipkin, W Ian
Format: Article
Language:English
Subjects:
Animals
Aquatic birds
Astroviridae - genetics
Astroviridae Infections - virology
Bays
Biology and Life Sciences
Bird Diseases - virology
Bird populations
Birds
Birds - virology
Coronaviridae
Coronavirus - genetics
Coronavirus Infections - virology
Coronaviruses
Cytochrome
Delaware
Feces
Feces - chemistry
Health care
Homology
Infections
Infectious diseases
Influenza
Life sciences
Medicine and Health Sciences
Migratory birds
Nephritis
Phylogenetics
Polymerase chain reaction
Public health
Severe acute respiratory syndrome
Surveillance
Viruses
West Nile virus
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Summary:Wild birds are an important but to some extent under-studied reservoir for emerging pathogens. We used unbiased sequencing methods for virus discovery in shorebird samples from the Delaware Bay, USA; an important feeding ground for thousands of migratory birds. Analysis of shorebird fecal samples indicated the presence of a novel astrovirus and coronavirus. A sanderling sample yielded sequences with distant homology to avian nephritis virus 1, an astrovirus associated with acute nephritis in poultry. A ruddy turnstone sample yielded sequences with homology to deltacoronaviruses. Our findings highlight shorebirds as a virus reservoir and the need to closely monitor wild bird populations for the emergence of novel virus variants.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0093395