Alteration of rat fetal cerebral cortex development after prenatal exposure to polychlorinated biphenyls

Polychlorinated biphenyls (PCBs) are environmental contaminants that persist in environment and human tissues. Perinatal exposure to these endocrine disruptors causes cognitive deficits and learning disabilities in children. These effects may involve their ability to interfere with thyroid hormone (...

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Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3), p.e91903
Main Authors: Naveau, Elise, Pinson, Anneline, Gérard, Arlette, Nguyen, Laurent, Charlier, Corinne, Thomé, Jean-Pierre, Zoeller, R Thomas, Bourguignon, Jean-Pierre, Parent, Anne-Simone
Format: Article
Language:English
Subjects:
Animal tissues
Animals
Aroclor 1254
Biology and Life Sciences
Brain
Breastfeeding & lactation
Cell cycle
Cell Cycle - drug effects
Cell Death
Cell Differentiation
Cell growth
Cell migration
Cell Movement
Cell Proliferation
Cerebral cortex
Cerebral Cortex - drug effects
Cerebral Cortex - growth & development
Cerebral Cortex - pathology
Children
Chlorinated solvents
Chlorodiphenyl (54% Chlorine) - pharmacology
Cognitive ability
Contaminants
Disabilities
Down-Regulation
Embryos
Endocrine disruptors
Endocrine Disruptors - pharmacology
Endocrinology
Enviromental Science
Environmental Pollutants - pharmacology
Exposure
Female
Fetus
Fetuses
Gene expression
Gestation
Human health sciences
Human tissues
Laboratories
Medicine and Health Sciences
Miljövetenskap
Neural stem cells
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neurogenesis
Neurons
Neurons - drug effects
Neurons - pathology
Neurosciences
PCB
PCB compounds
Pediatrics
Perinatal exposure
Polychlorinated biphenyls
Pregnancy
Prenatal experience
Prenatal exposure
Prenatal Exposure Delayed Effects - blood
Prenatal Exposure Delayed Effects - pathology
Prenatal Exposure Delayed Effects - physiopathology
Progenitor cells
Pédiatrie
Rats
Rodents
Sciences de la santé humaine
Thyroid
Thyroid gland
Thyroxine
Thyroxine - blood
Toxicology
Water pollution effects
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Summary:Polychlorinated biphenyls (PCBs) are environmental contaminants that persist in environment and human tissues. Perinatal exposure to these endocrine disruptors causes cognitive deficits and learning disabilities in children. These effects may involve their ability to interfere with thyroid hormone (TH) action. We tested the hypothesis that developmental exposure to PCBs can concomitantly alter TH levels and TH-regulated events during cerebral cortex development: progenitor proliferation, cell cycle exit and neuron migration. Pregnant rats exposed to the commercial PCB mixture Aroclor 1254 ended gestation with reduced total and free serum thyroxine levels. Exposure to Aroclor 1254 increased cell cycle exit of the neuronal progenitors and delayed radial neuronal migration in the fetal cortex. Progenitor cell proliferation, cell death and differentiation rate were not altered by prenatal exposure to PCBs. Given that PCBs remain ubiquitous, though diminishing, contaminants in human systems, it is important that we further understand their deleterious effects in the brain.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0091903