Semi-quantitative parameter analysis of DCE-MRI revisited: monte-carlo simulation, clinical comparisons, and clinical validation of measurement errors in patients with type 2 neurofibromatosis

To compare semi-quantitative (SQ) and pharmacokinetic (PK) parameters for analysis of dynamic contrast enhanced MR data (DCE-MRI) and investigate error-propagation in SQ parameters. Clinical data was collected from five patients with type 2-neurofibromatosis (NF2) receiving anti-angiogenic therapy f...

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Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3), p.e90300-e90300
Main Authors: Jackson, Alan, Li, Ka-Loh, Zhu, Xiaoping
Format: Article
Language:English
Subjects:
Biology
Biomarkers
Brain cancer
Breast cancer
Comparative analysis
Computer Simulation
Contrast Media
Datasets
Feasibility studies
Genetic disorders
Humans
Kinetics
Magnetic Resonance Imaging
Medical errors
Medical research
Medicine
Monte Carlo Method
Monte Carlo methods
Neurofibromatosis
Neurofibromatosis 2 - diagnosis
Neurological disorders
NMR
Nuclear magnetic resonance
Oncology
Reproducibility of Results
Statistics, Nonparametric
Tumors
Washout
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Summary:To compare semi-quantitative (SQ) and pharmacokinetic (PK) parameters for analysis of dynamic contrast enhanced MR data (DCE-MRI) and investigate error-propagation in SQ parameters. Clinical data was collected from five patients with type 2-neurofibromatosis (NF2) receiving anti-angiogenic therapy for rapidly growing vestibular schwannoma (VS). There were 7 VS and 5 meningiomas. Patients were scanned prior to therapy and at days 3 and 90 of treatment. Data was collected using a dual injection technique to permit direct comparison of SQ and PK parameters. Monte Carlo modeling was performed to assess potential measurement errors in SQ parameters in persistent, washout, and weakly enhancing tissues. The simulation predictions for five semi-quantitative parameters were tested using the clinical DCE-MRI data. In VS, SQ parameters and Ktrans showed close correlation and demonstrated similar therapy induced reductions. In meningioma, only the denoised Signal Enhancement Ratio (Rse1/se2(DN)) showed a significant therapy induced reduction (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0090300