Seven functional polymorphisms in the CETP gene and myocardial infarction risk: a meta-analysis and meta-regression

This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published befo...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e88118-e88118
Main Authors: Wang, Qi, Zhou, Shao-Bo, Wang, Li-Jie, Lei, Ming-Ming, Wang, Yong, Miao, Chi, Jin, Yuan-Zhe
Format: Article
Language:English
Subjects:
Alleles
Biology
Biomarkers
Cardiovascular disease
Case-Control Studies
CETP gene
Cholesterol Ester Transfer Proteins - genetics
Cohort Studies
Epidemiology
Genes
Genetic aspects
Genetic Markers
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Heart attack
Humans
Low density lipoprotein
Medicine
Meta-analysis
Myocardial infarction
Myocardial Infarction - genetics
Polymorphism
Polymorphism, Single Nucleotide
Regression Analysis
Risk analysis
Risk Factors
Scientific papers
Search engines
Studies
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Summary:This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before March 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Nine case-control studies with a total 8,623 MI cases and 8,564 healthy subjects met the inclusion criteria. The results of our meta-analysis suggested that CETP rs708272 (C>T) polymorphism might be correlated with an increased risk of MI, especially among Caucasians. Furthermore, we observed that CETP rs1800775 (C>A) polymorphism might increase the risk of MI. Nevertheless, no similar findings were found for CETP rs5882 (A>G), rs2303790 (A>G), rs1800776 (C>A), rs12149545 (G>A), and rs4783961 (G>A) polymorphisms. The current meta-analysis suggests that CETP rs708272 (C>T) and rs1800775 (C>A) polymorphisms may contribute to MI susceptibility, especially among Caucasians. Thus, CETP rs708272 and rs1800775 polymorphisms may be promising and potential biomarkers for early diagnosis of MI.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0088118