Porphyromonas gingivalis infection reduces regulatory T cells in infected atherosclerosis patients

Increasing evidence has shown periodontal pathogen Porphyromonas gingivalis (P.gingivalis) infection contributes to atherosclerosis (AS) progression. P.gingivalis fimbriae act as an important virulence factor in AS. Regulatory T cells (Tregs) may play a crucial role in autoimmune response during thi...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e86599-e86599
Main Authors: Yang, Jie, Wu, Juan, Liu, Yu, Huang, Jin, Lu, Zhipin, Xie, Liping, Sun, Weibin, Ji, Yong
Format: Article
Language:English
Subjects:
Aged
Analysis
Antibodies, Bacterial - blood
Arteriosclerosis
Atherosclerosis
Atherosclerosis - immunology
Atherosclerosis - microbiology
Atherosclerosis - pathology
Autoimmunity
Bacterial infections
Bacteroidaceae Infections - immunology
Bacteroidaceae Infections - microbiology
Bacteroidaceae Infections - pathology
Bone morphogenetic proteins
Cardiology
Cardiovascular disease
Carotid arteries
Case-Control Studies
Development and progression
Enzyme-Linked Immunosorbent Assay
Female
Fimbriae, Bacterial - pathology
Flow Cytometry
Genotypes
Gum disease
Health aspects
Heart attacks
Hospitals
Humans
Immune system
Immunoglobulin G - blood
Immunoregulation
Infection
Infections
Inflammatory diseases
Laboratories
Lymphocytes
Lymphocytes T
Male
Medical schools
Medicine
Middle Aged
Pathogenesis
Patients
Periodontitis
Periodontitis - immunology
Periodontitis - microbiology
Periodontitis - pathology
Pili
Porphyromonas gingivalis
Porphyromonas gingivalis - isolation & purification
T cells
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Transforming Growth Factor beta1 - blood
Transforming growth factor-b1
Transforming growth factors
Ultrasonic imaging
Veins & arteries
Virulence
Virulence factors
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Summary:Increasing evidence has shown periodontal pathogen Porphyromonas gingivalis (P.gingivalis) infection contributes to atherosclerosis (AS) progression. P.gingivalis fimbriae act as an important virulence factor in AS. Regulatory T cells (Tregs) may play a crucial role in autoimmune response during this process. However, whether P.gingivalis infection is associated with Tregs dysregulation during AS is still unknown and the prevalence of different P.gingivalis FimA genotypes during this process is unclear. Here we analyzed the distribution of Tregs and in P.gingivalis-infected atherosclerotic patients to reveal the relationship between P.gingivalis infection and Tregs reduction/dysfunction and to elucidate their role in periodontitis-AS interaction. FimA genotype was also examined to determine the prevalence of fimbriae. Our results showed that P.gingivalis infection reduced Tregs in atherosclerotic patients compared with non-atherosclerotic patients and health controls. Concentration of TGF-β1, which plays an important role in the development of Tregs, also decreased in P.gingivalis infected patients. Furthermore, type II FimA seems to show higher prevalence than the other five detected types. The population of Tregs further decreased in patients with type II FimA compared with the other types. P.gingivlias FimA genotype II was the dominant type associated with decreased Treg population. These results indicate that P.gingivalis infection may be associated with Tregs dysregulation in AS; type II FimA may be a predominant genotype in this process.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0086599