Pancreatitis-associated protein does not predict disease relapse in inflammatory bowel disease patients

The pancreatitis-associated protein (PAP) is increased in the serum of active inflammatory bowel disease (IBD) patients and its levels seem to be correlated with disease activity. Our aim was to evaluate the usefulness of serum and fecal PAP measurements to predict relapse in patients with inactive...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e84957-e84957
Main Authors: Nunes, Tiago, Etchevers, Maria Josefina, Sandi, Maria Jose, Pinó Donnay, Susana, Grandjean, Teddy, Pellisé, Maria, Panés, Julián, Ricart, Elena, Iovanna, Juan Lucio, Dagorn, Jean-Charles, Chamaillard, Mathias, Sans, Miquel
Format: Article
Language:English
Subjects:
Adult
Antigens, Neoplasm - blood
Bacteria
Biomarkers
Biomarkers, Tumor - blood
C-reactive protein
C-Reactive Protein - metabolism
Colitis, Ulcerative - blood
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - physiopathology
Crohn Disease - blood
Crohn Disease - diagnosis
Crohn Disease - physiopathology
Crohn's disease
Crohns disease
Diagnostic systems
Endoscopy
Feces
Feces - chemistry
Female
Gastroenterology
Gene expression
Gram-positive bacteria
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Lectins, C-Type - blood
Leukocyte L1 Antigen Complex - metabolism
Male
Medical diagnosis
Medical research
Medicine
Middle Aged
Pancreatitis
Pancreatitis-Associated Proteins
Pathogens
Patients
Prognosis
Prospective Studies
Proteins
Recurrence
Recurrence (Disease)
Remission
Severity of Illness Index
Ulcerative colitis
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Summary:The pancreatitis-associated protein (PAP) is increased in the serum of active inflammatory bowel disease (IBD) patients and its levels seem to be correlated with disease activity. Our aim was to evaluate the usefulness of serum and fecal PAP measurements to predict relapse in patients with inactive IBD. We undertook a 12-month prospective study that included 66 Crohn's disease (CD) and 74 ulcerative colitis (UC) patients. At inclusion, patients were in clinical remission, defined by a Harvey-Bradshaw (HB) Index≤4 (CD) or a partial Mayo Score (MS)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0084957