Zinc deficiency is common in several psychiatric disorders

Mounting evidence suggests a link between low zinc levels and depression. There is, however, little knowledge about zinc levels in older persons with other psychiatric diagnoses. Therefore, we explore the zinc status of elderly patients suffering from a wide range of psychiatric disorders. Clinical...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e82793-e82793
Main Authors: Grønli, Ole, Kvamme, Jan Magnus, Friborg, Oddgeir, Wynn, Rolf
Format: Article
Language:English
Subjects:
Addictions
Aged
Aged, 80 and over
Albumin
Alzheimer's disease
Analysis
Behavior disorders
Blood
Blood tests
Clinical medical disciplines: 750
Clinical medicine
Cognitive ability
Dementia
Dementia disorders
Depression (Mood disorder)
Depression - metabolism
Diagnostic systems
Disorders
Female
Geriatrics
Health sciences
Hospitals
Humans
Klinisk medisinske fag: 750
Male
Medical diagnosis
Medical disciplines: 700
Medical records
Medical research
Medisinske Fag: 700
Mental depression
Mental disorders
Mental Disorders - metabolism
Middle Aged
Neuropsychological Tests
Nutrient deficiency
Older people
Patients
Population
Population studies
Psychiatry
Psychiatry, child psychiatry: 757
Psychosis
Psykiatri, barnepsykiatri: 757
Serum albumin
Serum Albumin - metabolism
Sex Factors
Studies
Supplements
VDP
Zinc
Zinc (Nutrient)
Zinc - deficiency
Zinc - metabolism
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Summary:Mounting evidence suggests a link between low zinc levels and depression. There is, however, little knowledge about zinc levels in older persons with other psychiatric diagnoses. Therefore, we explore the zinc status of elderly patients suffering from a wide range of psychiatric disorders. Clinical data and blood samples for zinc analyzes were collected from 100 psychogeriatric patients over 64 of age. Psychiatric and cognitive symptoms were assessed using the Montgomery and Aasberg Depression Rating Scale, the Cornell Scale for Depression in Dementia, the Mini-Mental State Examination, the Clockdrawing Test, clinical interviews and a review of medical records. In addition, a diagnostic interview was conducted using the Mini International Neuropsychiatric Interview instrument. The prevalence of zinc deficiency in patients with depression was compared with the prevalence in patients without depression, and the prevalence in a control group of 882 older persons sampled from a population study. There was a significant difference in zinc deficiency prevalence between the control group (14.4%) and the patient group (41.0%) (χ(2) = 44.81, df = 1, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0082793