A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer

Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The...

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Bibliographic Details
Published in:	PLoS biology 2013-11, Vol.11 (11), p.e1001724-e1001724
Main Authors:	Cruz-Ramírez, Alfredo, Díaz-Triviño, Sara, Wachsman, Guy, Du, Yujuan, Arteága-Vázquez, Mario, Zhang, Hongtao, Benjamins, Rene, Blilou, Ikram, Neef, Anne B, Chandler, Vicki, Scheres, Ben
Format:	Article
Language:	eng
Subjects:	Amino Acid Sequence Arabidopsis - cytology Arabidopsis - metabolism Arabidopsis Proteins - chemistry Arabidopsis Proteins - metabolism Cell division Cell Proliferation clonal analysis cycle progression division dna-damage gene Gene Knockdown Techniques Genetic engineering in-vivo meristem Meristem - cytology Meristem - metabolism Protein Binding Protein Interaction Domains and Motifs Protein Interaction Maps Proteins replication stress self-renewal Stem Cell Niche Stem cells Stem Cells - physiology thaliana root
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Summary:	Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage.
ISSN:	1545-7885 1544-9173 1545-7885