Cardiac troponin I in non- acute coronary syndrome patients with chronic kidney disease

The aim of this study was to assess the results of troponin I (cTnI) in non- acute Coronary Syndrome (ACS) patients with chronic kidney disease (CKD). We also examined the risk factors for elevated cTnI in non-ACS patients with CKD and whether stage 5 CKD modifies the associations of elevated cTnI a...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e82752
Main Authors: Chen, Shanying, Huang, Chunhong, Wu, Bide, Lian, Xuejian, Mei, Xuqiao, Wan, Jianxin
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - complications
Acute Coronary Syndrome - diagnosis
Acute coronary syndromes
Adult
Aged
Aged, 80 and over
Analysis
Blood pressure
Calcification
Calcium-binding protein
Cardiac patients
Chronic kidney failure
Congestive heart failure
Coronary heart disease
Creatine Kinase, MB Form - blood
Diabetes
Failure analysis
Female
Health risks
Heart
Heart failure
Homocysteine
Humans
Immunoassay
Kidney diseases
Kidney transplantation
Laboratories
Male
Medical research
Middle Aged
Nephrology
Patients
Peritoneal dialysis
Regression analysis
Regression models
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - diagnosis
Retrospective Studies
Risk analysis
Risk Factors
Troponin
Troponin I
Troponin I - blood
Urine
Variables
Young Adult
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Summary:The aim of this study was to assess the results of troponin I (cTnI) in non- acute Coronary Syndrome (ACS) patients with chronic kidney disease (CKD). We also examined the risk factors for elevated cTnI in non-ACS patients with CKD and whether stage 5 CKD modifies the associations of elevated cTnI and the risk factors in non-ACS patients with CKD. A retrospective study was performed. Logistic regression models were used. 293 non-ACS patients with CKD were included in the current study. 43.34% non-ACS patients with CKD have an elevated cTnI level and 5.12% have an elevated cTnT level in MI range. In CKD patients without ACS and heart failure, only 26.03% (38/146) patients have an elevated cTnT level. In adjusted analyses, age, diastolic blood pressure and congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD (OR 2.30, 95% CI 1.08,4.88, P=0.03). Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level. 43.34% non-ACS patients with CKD and 26.03% CKD patients without ACS and congestive heart failure have an elevated cTnI level. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0082752