Fungal adenylyl cyclase acts as a signal sensor and integrator and plays a central role in interaction with bacteria

  New findings support a model that adenylyl cyclases act as a hub of signal sensing and integration and may play a central role in bacterial sensing during fungal infection. cAMP Signalling Plays a Major Role in Regulating Cellular Responses to Environmental Signals and in Virulence in C. albicans...

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Bibliographic Details
Published in:PLoS pathogens 2013-10, Vol.9 (10), p.e1003612-e1003612
Main Author: Wang, Yue
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Animals
Bacteria - metabolism
Bacterial Infections - metabolism
Candida albicans
Candida albicans - enzymology
Candidiasis - enzymology
Candidiasis - microbiology
Cellular signal transduction
Cyclic adenylic acid
Female
Fungal Proteins - metabolism
Fungi
Humans
Infections
Kinases
Male
Microbiology
Mortality
Pearls
Physiological aspects
Virulence (Microbiology)
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Summary:  New findings support a model that adenylyl cyclases act as a hub of signal sensing and integration and may play a central role in bacterial sensing during fungal infection. cAMP Signalling Plays a Major Role in Regulating Cellular Responses to Environmental Signals and in Virulence in C. albicans C. albicans is frequently found as a benign member of the normal microflora of humans. Fungal Adenylyl Cyclases Are Large Proteins Containing Various Functional Domains Providing Multiple Points for Signal Sensing Fungal Cyr1s contain several highly conserved domains (Figure 1), from the N- to C-terminus, including a Gα domain, a Ras-association (RA) domain, a leucine-rich repeat (LRR) domain, a protein phosphatase 2C (PP2C) domain, a cyclase catalytic (CYCc) domain, and a Cap1 (cyclase-associated protein 1) binding domain (CBD).
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003612