Long-lasting insecticidal nets are synergistic with mass drug administration for interruption of lymphatic filariasis transmission in Nigeria

In central Nigeria Anopheles mosquitoes transmit malaria and lymphatic filariasis (LF). The strategy used for interrupting LF transmission in this area is annual mass drug administration (MDA) with albendazole and ivermectin, but after 8 years of MDA, entomological evaluations in sentinel villages s...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2013-10, Vol.7 (10), p.e2508
Main Authors: Eigege, Abel, Kal, Alphonsus, Miri, Emmanuel, Sallau, Adamu, Umaru, John, Mafuyai, Hayward, Chuwang, Yohanna S, Danjuma, Goshit, Danboyi, Jacob, Adelamo, Solomon E, Mancha, Bulus S, Okoeguale, Bridget, Patterson, Amy E, Rakers, Lindsay, Richards, Frank O
Format: Article
Language:English
Subjects:
Albendazole - administration & dosage
Animals
Anopheles
Anopheles - drug effects
Anopheles - growth & development
Anopheles - parasitology
Communicable Disease Control - methods
Community
Comparative analysis
Disease transmission
Dissection
Donations
Elephantiasis, Filarial - drug therapy
Elephantiasis, Filarial - prevention & control
Elephantiasis, Filarial - transmission
Filariasis
Filaricides - administration & dosage
Health care
Health education
Humans
Infections
Insecticide-Treated Bednets - utilization
Insecticides - pharmacology
Ivermectin - administration & dosage
Malaria
Methods
Mosquitoes
Nigeria - epidemiology
Parasitic diseases
Pharmaceutical industry
Prevention
Tropical diseases
Vector control
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Description
Summary:In central Nigeria Anopheles mosquitoes transmit malaria and lymphatic filariasis (LF). The strategy used for interrupting LF transmission in this area is annual mass drug administration (MDA) with albendazole and ivermectin, but after 8 years of MDA, entomological evaluations in sentinel villages showed continued low-grade mosquito infection rates of 0.32%. After long-lasting insecticidal net (LLIN) distribution by the national malaria program in late 2010, however, we were no longer able to detect infected vectors over a 24-month period. This is evidence that LLINs are synergistic with MDA in interrupting LF transmission.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002508