Alterations of glucose-dependent insulinotropic polypeptide and expression of genes involved in mammary gland and adipose tissue lipid metabolism during pregnancy and lactation

Gastric inhibitory polypeptide (GIP) is a gut derived peptide with multiple emerging physiological actions. Effects of pregnancy and lactation on GIP secretion and related gene expression were studied in Wistar rats. Pregnancy moderately increased feeding (p

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Bibliographic Details
Published in:PloS one 2013-11, Vol.8 (11), p.e78560-e78560
Main Authors: Moffett, R Charlotte, Irwin, Nigel, Francis, Jacqueline M E, Flatt, Peter R
Format: Article
Language:English
Subjects:
Abdominal Fat - metabolism
Adaptation
Adaptations
Adipose tissue
Administration, Oral
Animals
Blood Glucose
Body fat
Diabetes
Dietary Fats - administration & dosage
Energy Intake
Female
Food intake
Gastric Inhibitory Polypeptide - blood
Gene expression
Gene Expression Regulation
Genes
GIP protein
Glucagon
Glucose
Homeostasis
Insulin
Insulin - blood
Insulin resistance
Intestine
Intestines - anatomy & histology
Kinases
Lactation
Lactation - metabolism
Lipid Metabolism
Mammary gland
Mammary Glands, Animal - metabolism
Metabolism
Neonates
Organ Size
Pancreas - cytology
Pancreas - metabolism
Physiological aspects
Physiological effects
Polypeptides
Pregnancy
Pregnancy - metabolism
Pregnant women
Proteins
Rats
Rats, Wistar
Regulation
Rodents
Secretion
Suckling behavior
Transcriptome
Weight control
Weight Gain
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Description
Summary:Gastric inhibitory polypeptide (GIP) is a gut derived peptide with multiple emerging physiological actions. Effects of pregnancy and lactation on GIP secretion and related gene expression were studied in Wistar rats. Pregnancy moderately increased feeding (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0078560