Does optic nerve head surface topography change prior to loss of retinal nerve fiber layer thickness: a test of the site of injury hypothesis in experimental glaucoma

To test the hypothesis that optic nerve head (ONH) deformation manifesting as changes in its mean surface height precedes thinning of the peripapillary retinal nerve fiber layer (RNFL) in experimental glaucoma (EG). 68 rhesus macaque monkeys each had three or more baseline imaging sessions under man...

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Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10), p.e77831-e77831
Main Authors: Fortune, Brad, Reynaud, Juan, Wang, Lin, Burgoyne, Claude F
Format: Article
Language:English
Subjects:
Animals
Change detection
Deformation
Deformation mechanisms
Dietary fiber
Disease Models, Animal
Eye
Eye (anatomy)
Eye injuries
Female
Glaucoma
Glaucoma - pathology
Glaucoma - surgery
Humans
Hypotheses
Intraocular Pressure
Laboratory animals
Macaca mulatta
Male
Medical imaging
Monkeys
Nerve Fibers - pathology
Optic Disk - pathology
Optic nerve
Optic Nerve - pathology
Optic Nerve Diseases - pathology
Retina
Retina - pathology
Signal detection
Thickness
Tomography
Topography
Trabecular Meshwork - surgery
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Summary:To test the hypothesis that optic nerve head (ONH) deformation manifesting as changes in its mean surface height precedes thinning of the peripapillary retinal nerve fiber layer (RNFL) in experimental glaucoma (EG). 68 rhesus macaque monkeys each had three or more baseline imaging sessions under manometric intraocular pressure (IOP) control to obtain average RNFL thickness (RNFLT) and the ONH surface topography parameter mean position of the disc (MPD). Laser photocoagulation was then applied to the trabecular meshwork of one eye to induce chronic, mild-to-moderate IOP elevation and bi-weekly imaging continued. Event analysis was applied to determine for each parameter when an 'endpoint' occurred (signficant change from baseline) for eight different endpoint criteria. Specificity was assessed in the group of 68 fellow control eyes. Classical signal detection theory and survival analysis were used to compare MPD with RNFLT. Regardless of the endpoint criterion, endpoints were always more frequent for MPD than for RNFLT. The discriminability index (d') was 2.7 ± 0.2 for MPD and 1.9 ± 0.2 for RNFLT (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0077831