A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype

Molecular classification of lung cancer correlates well with histomorphological features. However, specific histomorphological features that differentiate anaplastic lymphoma kinase (ALK)-rearranged tumors from ALK-negative tumors have not been fully evaluated. Eighty ALK-rearranged and 213 ALK-nega...

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Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10), p.e76999-e76999
Main Authors: Kim, Hyojin, Jang, Se Jin, Chung, Doo Hyun, Yoo, Seol Bong, Sun, Pingli, Jin, Yan, Nam, Kyung Han, Paik, Jin-Ho, Chung, Jin-Haeng
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
Aggressive behavior
Analysis
Analysis of Variance
Anaplastic Lymphoma Kinase
Biopsy
Bronchus
Cancer
Comparative analysis
Diagnosis
Diagnostic systems
E-cadherin
Epidermal growth factor
Epithelial-Mesenchymal Transition - genetics
FDA approval
Female
Genes, erbB-1 - genetics
Genes, ras - genetics
Genetic aspects
Histological Techniques
Humans
Immunohistochemistry
Invasiveness
K-Ras protein
Lung cancer
Lung diseases
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lymphoma
Male
Markers
Medical diagnosis
Mesenchyme
Metastases
Middle Aged
Mucin
Multivariate analysis
Mutation
Mutation - genetics
Neoplasm Invasiveness - genetics
Non-Hodgkin's lymphomas
Odds Ratio
Oncogenes
Pathology
Phenotype
Protein-tyrosine kinase
Receptor Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases - metabolism
Republic of Korea
Squamous cell carcinoma
Stem cells
Studies
Tumors
Vimentin
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Summary:Molecular classification of lung cancer correlates well with histomorphological features. However, specific histomorphological features that differentiate anaplastic lymphoma kinase (ALK)-rearranged tumors from ALK-negative tumors have not been fully evaluated. Eighty ALK-rearranged and 213 ALK-negative (91 epidermal growth factor receptor-mutated; 29 K-ras-mutated; 93 triple-negative) resected lung adenocarcinomas were analyzed for several histomorphological parameters and histological subtype. ALK-rearranged tumors were associated with younger age at presentation, frequent nodal metastasis, and higher stage of disease at diagnosis. ALK-rearranged tumors were more likely to show a solid predominant pattern than ALK-negative tumors (43.8%; 35/80; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0076999