Relationship between cerebrospinal fluid biomarkers for inflammation, demyelination and neurodegeneration in acute optic neuritis

Various inflammatory biomarkers show prognostic potential for multiple sclerosis (MS)-risk after clinically isolated syndromes. However, biomarkers are often examined singly and their interrelation and precise aspects of their associated pathological processes remain unclear. Clarification of these...

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Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10), p.e77163-e77163
Main Authors: Modvig, Signe, Degn, Matilda, Horwitz, Henrik, Cramer, Stig P, Larsson, Henrik B W, Wanscher, Benedikte, Sellebjerg, Finn, Frederiksen, Jette L
Format: Article
Language:English
Subjects:
Adult
Age
Biocompatibility
Biological markers
Biomarkers
Biomarkers - cerebrospinal fluid
Biomedical materials
Cerebrospinal fluid
Chitinase
Correlation analysis
Cumulative damage
CXCL10 protein
CXCL13 protein
Demyelinating Diseases - cerebrospinal fluid
Demyelinating Diseases - complications
Demyelination
Disabilities
Female
Gelatinase B
Humans
Immunoglobulin G
Infiltration
Inflammation
Inflammation - cerebrospinal fluid
Inflammation - complications
Lesions
Leukocytes
Magnetic resonance imaging
Male
Matrix metalloproteinase
Medical research
Metalloproteinase
Middle Aged
Multiple sclerosis
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - complications
Multiple Sclerosis - epidemiology
Myelin
Myelin basic protein
Myelin proteins
Neuritis
Neurodegeneration
Neurodegenerative Diseases - cerebrospinal fluid
Neurodegenerative Diseases - complications
Neurology
NMR
Nuclear magnetic resonance
Optic neuritis
Optic Neuritis - cerebrospinal fluid
Optic Neuritis - complications
Osteopontin
Parameters
Prospective Studies
Proteins
Risk
Risk Factors
Substantia alba
White blood cells
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Summary:Various inflammatory biomarkers show prognostic potential for multiple sclerosis (MS)-risk after clinically isolated syndromes. However, biomarkers are often examined singly and their interrelation and precise aspects of their associated pathological processes remain unclear. Clarification of these relationships could aid the appropriate implementation of prognostic biomarkers in clinical practice. To investigate the interrelation between biomarkers of inflammation, demyelination and neurodegeneration in acute optic neuritis and to assess their association to measures of MS risk. A prospective study at a tertiary referral centre from June 2011 to December 2012 of 56 patients with optic neuritis as a first demyelinating symptom and 27 healthy volunteers. Lumbar puncture was performed within 28 (median 16) days of onset. CSF levels of CXCL13, matrix metalloproteinase (MMP)-9, CXCL10, CCL-2, osteopontin and chitinase-3-like-1, myelin basic protein (MBP) and neurofilament light-chain (NF-L) were determined. MS-risk outcome measures were dissemination in space (DIS) of white matter lesions on cerebral MRI, CSF oligoclonal bands and elevated IgG-index. IN THE INTERRELATION ANALYSIS THE BIOMARKERS SHOWED CLOSE CORRELATIONS WITHIN TWO DISTINCT GROUPS: Biomarkers of leukocyte infiltration (CXCL13, MMP-9 and CXCL10) were strongly associated (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0077163