Human genetic susceptibility to invasive aspergillosis

  [...]of the impaired production of reactive oxygen species, patients with CGD often develop IA, typically within the first decade of life. [...]a nonsynonymous polymorphism in human plasminogen was found to increase risk for IA in HSCT recipients, particularly late after transplantation.

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Bibliographic Details
Published in:PLoS pathogens 2013-08, Vol.9 (8), p.e1003434-e1003434
Main Authors: Cunha, Cristina, Aversa, Franco, Romani, Luigina, Carvalho, Agostinho
Format: Article
Language:English
Subjects:
Allografts
Aspergillosis - genetics
Aspergillosis - immunology
Aspergillosis - prevention & control
Biology
Genetic Predisposition to Disease
Hematopoietic Stem Cell Transplantation
Humans
Immune system
Infections
Medical research
Medicine
Mortality
Organ Transplantation
Pearls
Risk Factors
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Description
Summary:  [...]of the impaired production of reactive oxygen species, patients with CGD often develop IA, typically within the first decade of life. [...]a nonsynonymous polymorphism in human plasminogen was found to increase risk for IA in HSCT recipients, particularly late after transplantation.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003434