The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility

Previous studies have investigated the association between single nucleotide polymorphisms (SNPs) located in microRNAs (miRNAs) and breast cancer susceptibility; however, because of their limited statistical power, many discrepancies are revealed in these studies. The meta-analysis presented here ai...

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Bibliographic Details
Published in:PloS one 2013-09, Vol.8 (9), p.e70656-e70656
Main Authors: Wang, Ping-Yu, Gao, Zong-Hua, Jiang, Zhong-Hua, Li, Xin-Xin, Jiang, Bao-Fa, Xie, Shu-Yang
Format: Article
Language:English
Subjects:
Analysis
Breast cancer
Breast Neoplasms - genetics
Cancer
Case-Control Studies
Chromosomes
Confidence intervals
Disease susceptibility
Epidemiology
Female
Gene Frequency
Genes
Genetic aspects
Genetic Association Studies
Genetic Predisposition to Disease
Genotypes
Health aspects
Health risk assessment
Health risks
Humans
Liver cancer
Medical ethics
Meta-analysis
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Oncology, Experimental
Polymorphism, Single Nucleotide
Public health
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Statistical analysis
Studies
Xin Li
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Summary:Previous studies have investigated the association between single nucleotide polymorphisms (SNPs) located in microRNAs (miRNAs) and breast cancer susceptibility; however, because of their limited statistical power, many discrepancies are revealed in these studies. The meta-analysis presented here aimed to identify and characterize the roles of miRNA SNPs in breast cancer risk, and evaluate the associations of polymorphisms in miR-146a rs2910164, miR-196a rs11614913 and miR-499 rs3746444 with breast cancer susceptibility, respectively. The PubMed and Embases databases were searched updated to 31(st) December, 2012. The complete data of polymorphisms in miR-146a rs2910164, miR-196a rs11614913 and miR-499 rs3746444 from case-control studies for breast cancer were analyzed by odds ratios (ORs) with 95% confidence intervals (CIs) to reveal the associations of SNPs in miRNAs with breast cancer susceptibility. Totally, six studies for rs2910164 in miR-146a, involving 4225 cases and 4469 controls; eight studies for rs11614913 in miR-196a, involving 4110 cases and 5100 controls; and three studies of rs3746444 in miR-499, involving 2588 cases and 3260 controls, were investigated in the meta-analysis. The rs11614913 (TT+CT) genotype of miR-196a2 was revealed to be associated with a decreased breast cancer susceptibility compared with the CC genotypes (OR = 0.906, 95% CI: 0.825-0.995, P = 0.039); however, no significant associations were observed between rs2910164 in miR-146a (or rs3746444 in miR-499) and breast cancer susceptibility. This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0070656