Hepatic parenchymal changes following transcatheter embolization and chemoembolization in a rabbit tumor model

To compare the effects of transcatheter arterial chemoembolization (TACE) with transcatheter arterial embolization (TAE) on liver function, hepatic damage, and hepatic fibrogenesis in a rabbit tumor model. Thirty-nine New Zealand white rabbits implanted with VX2 tumors in the left liver lobes were r...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e70757
Main Authors: Wang, Yong, Xiong, Bin, Liang, Bin, Zhao, Hui, Li, Hui, Qian, Jun, Liang, Hui-Min, Feng, Gan-Sheng, Zheng, Chuan-Sheng
Format: Article
Language:English
Subjects:
Actin
Alanine
Alanine transaminase
Alcohols
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Aspartate
Aspartate aminotransferase
Biology
Catheters
Cell activation
Chemoembolization
Chemoembolization, Therapeutic - adverse effects
Chemoembolization, Therapeutic - instrumentation
Collagen
Contrast agents
Damage
Disease Models, Animal
Distilled water
Embolization
Fibrosis
Gangrene
Hepatic artery
Hepatic Stellate Cells - drug effects
Hepatic Stellate Cells - pathology
Hypoxia
Laboratory animals
Liver
Liver - drug effects
Liver - pathology
Liver - physiopathology
Liver cancer
Liver diseases
Liver Function Tests
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Lobes
Medicine
Muscle proteins
Muscles
Necrosis - chemically induced
NMR
Nuclear magnetic resonance
Polyvinyl alcohol
Rabbits
Rodents
Satellite radio
Science
Smooth muscle
Statistical analysis
Statistical methods
Tumors
Veins & arteries
Water treatment
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Summary:To compare the effects of transcatheter arterial chemoembolization (TACE) with transcatheter arterial embolization (TAE) on liver function, hepatic damage, and hepatic fibrogenesis in a rabbit tumor model. Thirty-nine New Zealand white rabbits implanted with VX2 tumors in the left liver lobes were randomly divided into three groups: TAE, TACE, and control group. In the TAE group (n = 15), polyvinyl alcohol particles (PVAs) were used for left hepatic artery embolization. In the TACE group (n = 15), the tumors were treated with left hepatic arterial infusions of a suspension of 10-hydroxycamptothecin and lipiodol, followed by embolization with PVAs. In the control group (n = 9), the animals received sham treatment with distilled water. Serum and liver samples were collected at 6 hours, 3 days and 7 days after treatment. Liver damage was measured using a liver function test and histological analyses. Liver fibrogenesis and hepatic stellate cell (HSC) activation were evaluated using Sirius Red and anti-alpha-smooth muscle actin (α-SMA) immunohistochemical stains. TACE caused liver injury with greater increases in serum alanine aminotransferase and aspartate aminotransferase levels on day 3 (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0070757