Increased serum oxidative stress markers in women with uterine leiomyoma

Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbony...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e72069-e72069
Main Authors: Santulli, Pietro, Borghese, Bruno, Lemaréchal, Herve, Leconte, Mahaut, Millischer, Anne-Elodie, Batteux, Frédéric, Chapron, Charles, Borderie, Didier
Format: Article
Language:English
Subjects:
Adult
Advanced Oxidation Protein Products - blood
Antioxidants
Arthritis
Biochemistry
Biomarkers - blood
Blood proteins
Blood Proteins - metabolism
Carbonyl compounds
Carbonyl groups
Carbonyls
Case-Control Studies
Cell growth
Disease
Extracellular matrix
Female
Fibroids
Growth factors
Gynecology
Humans
Hysterectomy
Infertility
Laboratories
Leiomyoma
Leiomyoma - blood
Leiomyoma - diagnosis
Leiomyoma - pathology
Markers
Medical research
Medicine
Menopause
Metastasis
Middle Aged
Nitrates
Nitrates - blood
Nitrites
Nitrites - blood
Oxidation
Oxidative Stress
Pathogenesis
Patients
Premenopause - blood
Protein Carbonylation
Reproductive health
Smooth muscle
Sulfhydryl Compounds - blood
Surgery
Thiols
Tumors
Uterine Neoplasms - blood
Uterine Neoplasms - diagnosis
Uterine Neoplasms - pathology
Uterus
Womens health
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Summary:Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the abdominopelvic cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0072069