Upregulated expression of C-X-C chemokine receptor 4 is an independent prognostic predictor for patients with gastric cancer

Aberrant chemokine (C-X-C motif) receptor CXCR4 expressions in malignant tissues have been reported, but its role in gastric cancer prognosis remains unknown. Our studies were designed to investigate the expression and prognostic significance of CXCR4 in patients with gastric cancer. CXCR4 expressio...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e71864-e71864
Main Authors: He, Hongyong, Wang, Cong, Shen, Zhenbin, Fang, Yong, Wang, Xuefei, Chen, Weidong, Liu, Fenglin, Qin, Xinyu, Sun, Yihong
Format: Article
Language:English
Subjects:
Aberration
Adenocarcinoma
Analysis
Cancer
Cancer patients
Cancer therapies
Cell membranes
Chemokines
Chemotherapy
CXCR4 protein
Cytoplasm
Female
Gastric cancer
Gastroenterology
Humans
Immunohistochemistry
Male
Medical prognosis
Membranes
Metastasis
Middle Aged
Neoplasm Staging
Oncology, Experimental
Patients
Prognosis
Receptors, CXCR4 - metabolism
Regression analysis
Stomach cancer
Stomach Neoplasms - diagnosis
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Surgery
Survival
Survival Analysis
Systematic review
Tissues
Up-Regulation
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Summary:Aberrant chemokine (C-X-C motif) receptor CXCR4 expressions in malignant tissues have been reported, but its role in gastric cancer prognosis remains unknown. Our studies were designed to investigate the expression and prognostic significance of CXCR4 in patients with gastric cancer. CXCR4 expression was retrospectively analyzed by immunohistochemistry in 97 patients with gastric adenocarcinoma from China. Results were assessed for association with clinical features and overall survival by using Kaplan-Meier analysis. Prognostic values of CXCR4 expression and clinical outcomes were evaluated by Cox regression analysis. A molecular prognostic stratification scheme incorporating CXCR4 expression was determined by using receiver operating characteristic (ROC) analysis. The results show that CXCR4 predominantly localized in the cell membranes and cytoplasm. The protein level of CXCR4 was upregulation in gastric cancer tissues and upregulated expression of CXCR4 was only significantly associated with Lauren classification (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0071864