Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population

Coronary artery disease is very common in Pakistani population. Some of the studies carried out on Western populations have shown a relationship between body iron status as determined by the ratio of concentrations of serum soluble transferrin receptor (sTfR) to ferritin and the risk of acute myocar...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e67981-e67981
Main Authors: Iqbal, Mohammad Perwaiz, Mehboobali, Naseema, Tareen, Asal Khan, Yakub, Mohsin, Iqbal, Saleem Perwaiz, Iqbal, Khalida, Haider, Ghulam
Format: Article
Language:English
Subjects:
Adult
Age
Asian Continental Ancestry Group
Biology
Blood
Blood levels
Cardiovascular disease
Cardiovascular diseases
Case-Control Studies
Cholesterol
Cholesterol - blood
Coronary artery
Coronary artery disease
Coronary vessels
Cyanocobalamin
Diabetes
Female
Females
Ferritin
Ferritins - blood
Folic acid
Folic Acid - blood
Heart attacks
Heart diseases
High density lipoprotein
Homocysteine
Humans
Infarction
Informed consent
Iron
Iron - blood
Iron - metabolism
Laboratories
Lead
Lead content
Lipoproteins (high density)
Lipoproteins (low density)
Liver diseases
Low density lipoprotein
Low income groups
Male
Males
Medicine
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - metabolism
Oxidative stress
Pakistan
Patients
Population
Population studies
Receptors, Transferrin - blood
Risk
Risk Factors
Studies
Transferrin
Triglycerides
Triglycerides - blood
Vitamin B
Vitamin B 12 - blood
Vitamin B12
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coronary artery disease is very common in Pakistani population. Some of the studies carried out on Western populations have shown a relationship between body iron status as determined by the ratio of concentrations of serum soluble transferrin receptor (sTfR) to ferritin and the risk of acute myocardial infarction (AMI). In order to investigate whether increased body iron status has any relationship with the risk of premature AMI in Pakistani population, a case-control study was carried out. In this case-control study, 203 consecutive AMI patients [146 males and 57 females; age range 18-45 years] admitted to the National Institute for Cardiovascular Diseases, Karachi, were enrolled with informed consent. In addition, 205 healthy controls whose gender and age (within 3 years) matched the patients, and who had a similar socio-economic background were recruited. Fasting venous blood was obtained and assessed for plasma/serum folate, vitamin B12, homocysteine, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, sTfR and ferritin and blood lead. It was found that serum concentration of ferritin and blood lead levels were significantly higher in AMI patients compared to their age and gender-matched healthy controls (p value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0067981