Arterial baroreceptor reflex counteracts long-term blood pressure increase in the rat model of renovascular hypertension

The present study tested the hypothesis that long-term effects of baroreceptor activation might contribute to the prevention of persistent arterial blood pressure (BP) increase in the rat model of renovascular hypertension (HTN). Repetitive arterial baroreflex (BR) testing was performed in normo- an...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e64788-e64788
Main Authors: Tsyrlin, Vitaly A, Galagudza, Michael M, Kuzmenko, Nataly V, Pliss, Michael G, Rubanova, Nataly S, Shcherbin, Yury I
Format: Article
Language:English
Subjects:
Animals
Arterial Pressure
Baroreceptors
Baroreflex
Biology
Blood
Blood pressure
Cardiovascular disease
Denervation
Disease Models, Animal
Endocrinology
Experiments
Heart
Heart - innervation
Heart - physiopathology
Heart diseases
Heart Rate
Hypertension
Hypertension, Renovascular - physiopathology
Hypotheses
Kidney - innervation
Kidney - physiopathology
Laboratory animals
Long-term effects
Male
Mathematics
Medicine
Nervous system
Pressoreceptors - physiopathology
Prevention
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Wistar
Reflexes
Renal artery
Renal Artery - physiopathology
Renovascular hypertension
Rodents
Sensitivity
Studies
Sympathetic Nervous System - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study tested the hypothesis that long-term effects of baroreceptor activation might contribute to the prevention of persistent arterial blood pressure (BP) increase in the rat model of renovascular hypertension (HTN). Repetitive arterial baroreflex (BR) testing was performed in normo- and hypertensive rats. The relationship between initial arterial BR sensitivity and severity of subsequently induced two-kidney one-clip (2K1C) renovascular HTN was studied in Wistar rats. Additionally, the time course of changes in systolic BP (SBP) and cardiac beat-to-beat (RR) interval was studied for 8 weeks after the induction of 2K1C renovascular HTN in the rats with and without sinoaortic denervation (SAD). In a separate experimental series, cervical sympathetic nerve activity (cSNA) was assessed in controls, 2K1C rats, WKY rats, and SHR. The inverse correlation between arterial BR sensitivity and BP was observed in the hypertensive rats during repetitive arterial BR testing. The animals with greater initial arterial BR sensitivity developed lower BP values after renal artery clipping than those with lower initial arterial BR sensitivity. BP elevation during the first 8 weeks of renal artery clipping in 2K1C rats was associated with decreased sensitivity of arterial BR. Although SAD itself resulted only in greater BP variability but not in persistent BP rise, the subsequent renal artery clipping invariably resulted in the development of sustained HTN. The time to onset of HTN was found to be shorter in the rats with SAD than in those with intact baroreceptors. cSNA was significantly greater in the 2K1C rats than in controls. Arterial BR appears to be an important mechanism of long-term regulation of BP, and is believed to be involved in the prevention of BP rise in the rat model of renovascular HTN.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0064788