Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes

Circulating Fibroblast Growth Factor 21 (FGF21) levels are increased in insulin resistant states such as obesity, type 2 diabetes mellitus and gestational diabetes mellitus (GDM). In addition, GDM is associated with serious maternal and fetal complications. We sought to study human cerebrospinal flu...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e65254-e65254
Main Authors: Tan, Bee K, Sivakumar, Kavitha, Bari, Muhammad F, Vatish, Manu, Randeva, Harpal S
Format: Article
Language:English
Subjects:
Adult
Age
Biology
Blood Glucose - metabolism
Body mass
Cerebrospinal fluid
Complications
Conditioning
Development and progression
Diabetes mellitus
Diabetes, Gestational - blood
Diabetes, Gestational - cerebrospinal fluid
Diabetes, Gestational - physiopathology
Enzyme-Linked Immunosorbent Assay
Explants
Female
Fetuses
Fibroblast growth factors
Fibroblast Growth Factors - blood
Fibroblast Growth Factors - cerebrospinal fluid
Genetic aspects
Gestational diabetes
Glucose
Humans
Insulin
Insulin - blood
Insulin Resistance
Medicine
Middle Aged
Pathogenesis
Physiological aspects
Placenta
Placenta - metabolism
Pregnancy
Pregnant women
Rodents
Secretion
Womens health
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Summary:Circulating Fibroblast Growth Factor 21 (FGF21) levels are increased in insulin resistant states such as obesity, type 2 diabetes mellitus and gestational diabetes mellitus (GDM). In addition, GDM is associated with serious maternal and fetal complications. We sought to study human cerebrospinal fluid (CSF) and corresponding circulating FGF21 levels in women with gestational diabetes mellitus (GDM) and in age and BMI matched control subjects. We also assessed FGF21 secretion from GDM and control human placental explants. CSF and corresponding plasma FGF21 levels of 24 women were measured by ELISA [12 GDM (age: 26-47 years, BMI: 24.3-36.3 kg/m(2)) and 12 controls (age: 22-40 years, BMI: 30.1-37.0 kg/m(2))]. FGF21 levels in conditioned media were secretion from GDM and control human placental explants were also measured by ELISA. Glucose, HOMA-IR and circulating NEFA levels were significantly higher in women with GDM compared to control subjects. Plasma FGF21 levels were significantly higher in women with GDM compared to control subjects [234.3 (150.2-352.7) vs. 115.5 (60.5-188.7) pg/ml; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0065254