TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion

Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival fact...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e64885-e64885
Main Authors: Oulidi, Agathe, Bokhobza, Alexandre, Gkika, Dimitra, Vanden Abeele, Fabien, Lehen'kyi, V'yacheslav, Ouafik, L'houcine, Mauroy, Brigitte, Prevarskaya, Natalia
Format: Article
Language:English
Subjects:
Adrenomedullin
Adrenomedullin - pharmacology
Amino acids
Angiogenesis
Biology
Bladder
Bladder cancer
Calcium
Cancer
Cell adhesion
Cell adhesion & migration
Cell Adhesion - drug effects
Cell Adhesion - genetics
Cell Line, Tumor
Cell Membrane - metabolism
Cell migration
Cell Movement - drug effects
Cell Movement - genetics
Cell survival
Humans
Invasiveness
Kinases
Life Sciences
Male
Medicine
Metastases
Mitogenic factor
Neoplasm Invasiveness
Pheochromocytoma
Phosphatidylinositol 3-Kinases - metabolism
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Protein Transport
Science
Signal Transduction
Survival factor
Tissues
Transient receptor potential proteins
Translocation
TRPV Cation Channels - genetics
TRPV Cation Channels - metabolism
Tumor cell lines
Urethral Neoplasms - genetics
Urethral Neoplasms - metabolism
Urethral Neoplasms - pathology
Urinary bladder
Urothelial cancer
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Summary:Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival factor for certain cancer cells. Some data suggest that AM might be involved in the progression cancer metastasis via angiogenesis and cell migration and invasion control. The Transient Receptor Potential channel TRPV2 is known to promote in prostate cancer cell migration and invasive phenotype and is correlated with the stage and grade of bladder cancer. In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0064885