Vagal afferent mediates the anorectic effect of peripheral secretin

Secretin (SCT) is a classical peptide hormone that is synthesized and released from the gastrointestinal tract after a meal. We have previously shown that it acts both as a central and peripheral anorectic peptide, and that its central effect is mediated via melanocortin system. As peripheral satiet...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e64859-e64859
Main Authors: Chu, Jessica Y S, Cheng, Carrie Y Y, Sekar, Revathi, Chow, Billy K C
Format: Article
Language:English
Subjects:
Abdomen
Animals
Appetite
Appetite Depressants - pharmacology
Arcuate nucleus
Binding sites
Biology
Blood-brain barrier
Brain
Brain stem
Brain Stem - cytology
Brain Stem - drug effects
Brain Stem - metabolism
Brain Stem - physiology
Capsaicin
Eating - drug effects
Endocrinology
Food
Food intake
Fos protein
Gastrointestinal tract
Hypothalamus
Male
Medicine
Melanocortin
Mesencephalon
Mice
Nerves
Neurons
Neurons, Afferent - cytology
Neurons, Afferent - drug effects
Neurons, Afferent - metabolism
Neurons, Afferent - physiology
Peptides
Physiology
Pro-Opiomelanocortin - metabolism
Proopiomelanocortin
Rodents
Satiety
Secretin
Secretin - pharmacology
Sensory neurons
Studies
vagotomy
Vagus nerve
Vagus Nerve - cytology
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Description
Summary:Secretin (SCT) is a classical peptide hormone that is synthesized and released from the gastrointestinal tract after a meal. We have previously shown that it acts both as a central and peripheral anorectic peptide, and that its central effect is mediated via melanocortin system. As peripheral satiety signals from the gastrointestinal tract can be sent to the brain via the vagal afferent or by crossing the blood-brain barrier (BBB), we therefore sought to investigate the pathway by which peripheral SCT reduces appetite in this study. It is found that bilateral subdiaphragmatic vagotomy and treatment of capsaicin, an excitotoxin for primary afferent neurons, could both block the anorectic effect of peripherally injected SCT. These treatments are found to be capable of blunting i.p. SCT-induced Fos activation in pro-opiomelanocortin (POMC) neurons within the hypothalamic Arcuate Nucleus (Arc). Moreover, we have also found that bilateral midbrain transaction could block feeding reduction by peripheral SCT. Taken together, we conclude that the satiety signals of peripheral SCT released from the gastrointestinal tract are sent via the vagus nerves to the brainstem and subsequently Arc, where it controls central expression of other regulatory peptides to regulate food intake.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0064859