Comparison of rapid diagnostic tests for the detection of Plasmodium vivax malaria in South Korea

South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e64353-e64353
Main Authors: Kim, Jung-Yeon, Ji, So-Young, Goo, Youn-Kyoung, Na, Byoung-Kuk, Pyo, Hyo-Joo, Lee, Han-Na, Lee, Juyoung, Kim, Nam Hee, von Seidlein, Lorenz, Cheng, Qin, Cho, Shin-Hyung, Lee, Won-Ja
Format: Article
Language:English
Subjects:
Accuracy
Antigens
Biology
Blood tests
Comparative analysis
Diagnostic systems
Diagnostic tests
Diagnostic Tests, Routine - methods
Disease control
Disease prevention
Engineering
Genomes
Genomics
Health facilities
Humans
Malaria
Malaria, Vivax - diagnosis
Malaria, Vivax - parasitology
Medical diagnosis
Medical laboratories
Medical research
Medicine
Microscopy
Parasitemia - parasitology
Parasites
Parasitic diseases
Parasitology
Plasmodium
Plasmodium falciparum
Plasmodium vivax
Plasmodium vivax - isolation & purification
Polymerase Chain Reaction
Product testing
R&D
Republic of Korea
Research & development
Sensitivity and Specificity
Surveillance
Vector-borne diseases
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Summary:South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated by comparing the four RDTs against the standard of nested-PCR and microscopic examination. The CareStart(TM) and SD Bioline had higher test sensitivities (99.4 and 98.8%, respectively) compared with the NanoSign and Asan Easy tests (93.0 and 94.7%, respectively). The CareStart(TM) and SD Bioline tests could detect P. vivax in samples with parasite densities
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0064353