Addition of a novel, protective family history category allows better profiling of cardiovascular risk and atherosclerotic burden in the general population. The Asklepios Study

Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) in a first-degree relative. We t...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e63185-e63185
Main Authors: Van daele, Caroline M, De Meyer, Tim, De Buyzere, Marc L, Gillebert, Thierry C, Denil, Simon L I J, Bekaert, Sofie, Chirinos, Julio A, Segers, Patrick, De Backer, Guy G, De Bacquer, Dirk, Rietzschel, Ernst R
Format: Article
Language:English
Subjects:
Abnormalities
Adult
Arteriosclerosis
Atherosclerosis
Atherosclerosis - diagnosis
Atherosclerosis - epidemiology
Atherosclerosis - pathology
Atherosclerosis - physiopathology
Bioinformatics
Biology
Blood pressure
Breakpoints
Cardiovascular disease
Cardiovascular diseases
Clinical medicine
Coronary Vessels - pathology
Coronary Vessels - physiopathology
Diabetes
Disease prevention
Families & family life
Family
Family medical history
Fasting
Female
Genetics
Health care
Health risk assessment
Health risks
Health sciences
Heart
Hospitals
Humans
Hypertension
Informed consent
Male
Medicine
Metabolic syndrome
Middle Aged
Phenotype
Population
Population studies
Preventive medicine
Public health
Questionnaires
Risk assessment
Risk Assessment - methods
Risk factors
Ultrasound
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Summary:Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) in a first-degree relative. We tested the added value of a new, extended family history definition (eFH), also taking into account later onset of disease, second-degree relatives and number of affected relatives, on profiling cardiovascular risk and atherosclerotic burden in the general population. Longitudinal population study. Random, representative population sample from Erpe-Mere and Nieuwerkerken (Belgium, primary care). 2524 male/female volunteers, aged 35-55 years, free from overt CVD. Subjects were extensively phenotyped including presence of atherosclerosis (ultrasound) and a newly developed FH questionnaire (4 generations). Compared to cFH, eFH was superior in predicting an adverse risk profile (glycemic state, elevated blood pressure, lipid abnormalities, presence of metabolic syndrome components) and presence of atherosclerosis (all age & sex-adjusted p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0063185