Prognostic value of metastatic axillary lymph node ratio for Chinese breast cancer patients

The prevalence of breast cancer varies among countries and regions. This retrospective study investigated the prognostic value of the lymph node ratio (LNR) compared with the number of positive lymph nodes (pN) in Chinese breast cancer patients. The medical records of female breast cancer patients (...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e61410-e61410
Main Authors: Wu, San-Gang, He, Zhen-Yu, Li, Qun, Sun, Jia-Yuan, Li, Feng-Yan, Lin, Qin, Lin, Huan-Xin, Guan, Xun-Xing
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Adult
Asian Continental Ancestry Group
Axilla
Biology
Biomarkers - metabolism
Biopsy
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - genetics
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer
Cancer metastasis
Cancer patients
Cancer research
Cancer therapies
Care and treatment
Chemotherapy
Comparative analysis
Disease
Disease-Free Survival
ErbB-2 protein
Estrogens
Female
Gene Expression
Hospitals
Humans
Laboratories
Lumpectomy
Lymph nodes
Lymph Nodes - metabolism
Lymph Nodes - pathology
Lymphatic Metastasis
Lymphatic system
Mastectomy
Medical prognosis
Medical records
Medicine
Metastases
Metastasis
Middle Aged
Multivariate analysis
Neoplasm Staging
Oncology
Patients
Progesterone
Prognosis
Radiation therapy
Receptor, ErbB-2 - genetics
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Receptors, Progesterone - genetics
Receptors, Progesterone - metabolism
Retrospective Studies
Studies
Surgery
Survival
Women's health
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Summary:The prevalence of breast cancer varies among countries and regions. This retrospective study investigated the prognostic value of the lymph node ratio (LNR) compared with the number of positive lymph nodes (pN) in Chinese breast cancer patients. The medical records of female breast cancer patients (N = 2591) were retrospectively evaluated. The association of LNR and TMN staging system were compared with respect to overall, disease-free, and distant metastasis-free survival. Out of 2591 patients, 2495 underwent modified radical surgery and 96 received breast conserving surgery. All patients had adjuvant chemotherapy following surgery. The median follow up period 66.9 months (range 5-168 months). The 5-year and 10-year overall survival rates were 89.3% and 78.8%, respectively, and 5-year disease-free survival and distant metastasis-free survival rates were 81.6% and 83.5%, respectively. Univariate analysis indicated that in general T, pN, LNR, as well as tumor expression of the estrogen receptor, progesterone receptor, and HER2 were associated with overall, disease-free, and distant metastasis-free survival (all P-values
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0061410