Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program

One of the most common integrative medicine (IM) modalities is yoga and related practices. Previous work has shown that yoga may improve wellness in healthy people and have benefits for patients. However, the mechanisms of how yoga may positively affect the mind-body system are largely unknown. Here...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e61910-e61910
Main Authors: Qu, Su, Olafsrud, Solveig Mjelstad, Meza-Zepeda, Leonardo A, Saatcioglu, Fahri
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bioinformatics
Biological effects
Biology
Blood
Breathing
Breathing exercises
Cancer
Comparative analysis
Exercise
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Genes
Genomics
Health aspects
Humans
Leukocytes (mononuclear)
Leukocytes, Mononuclear - metabolism
Lymphocytes
Male
Medical research
Medicine
Meditation
Middle Aged
Oligonucleotide Array Sequence Analysis
Oxidative stress
Peripheral blood mononuclear cells
Preventive maintenance
Principal components analysis
Respiration
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sports medicine
Studies
Yoga
Young Adult
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Summary:One of the most common integrative medicine (IM) modalities is yoga and related practices. Previous work has shown that yoga may improve wellness in healthy people and have benefits for patients. However, the mechanisms of how yoga may positively affect the mind-body system are largely unknown. Here we have assessed possible rapid changes in global gene expression profiles in the peripheral blood mononuclear cells (PBMCs) in healthy people that practiced either a comprehensive yoga program or a control regimen. The experimental sessions included gentle yoga postures, breathing exercises, and meditation (Sudarshan Kriya and Related Practices--SK&P) compared with a control regimen of a nature walk and listening to relaxing music. We show that the SK&P program has a rapid and significantly greater effect on gene expression in PBMCs compared with the control regimen. These data suggest that yoga and related practices result in rapid gene expression alterations which may be the basis for their longer term cell biological and higher level health effects.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0061910