Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications

Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that results from massive loss of hepatocytes and may lead to hepatic encephalopathy (HE), a serious neuropsychiatric complication. Although increased expression of tumor necrosis factor-alpha (TNF-α) in liver, p...

Full description

Bibliographic Details

Published in:	PloS one 2012-11, Vol.7 (11), p.e49670
Main Authors:	Chastre, Anne, Bélanger, Mireille, Beauchesne, Elizabeth, Nguyen, Bich N, Desjardins, Paul, Butterworth, Roger F
Format:	Article
Language:	eng
Subjects:	Ammonia Ammonia - blood Analgesics Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Attenuation Azoxymethane Azoxymethane - adverse effects Biology Brain Brain research Cascades CD40 Ligand - blood CD40L protein Cerebrum - drug effects Cerebrum - metabolism Coma Complications Complications and side effects Cytokines Disease Progression Edema Encephalopathy Etanercept Experiments Glutathione Hepatic encephalopathy Hepatic Encephalopathy - drug therapy Hepatic Encephalopathy - etiology Hepatic Encephalopathy - metabolism Hepatocytes Hepatotoxicity Immunoglobulin G - administration & dosage Immunoglobulin G - pharmacology Immunoglobulins Immunoreactivity Inflammation Injuries Interleukin 6 Interleukin-6 - blood Ischemia Ligands Liver Liver - drug effects Liver - metabolism Liver - pathology Liver diseases Liver failure Liver Failure, Acute - chemically induced Liver Failure, Acute - complications Liver Failure, Acute - drug therapy Liver Failure, Acute - metabolism Liver transplantation Liver transplants Male Medicine Mice Microglia - drug effects Microglia - metabolism Necrosis Neurological complications Neurosciences Organ transplantation Oxidative Stress - drug effects Persistent vegetative state Receptors, Tumor Necrosis Factor - administration & dosage Rheumatoid arthritis Rodents Transaminase Transplantation Transplantation of organs, tissues, etc Transplants & implants Tumor necrosis factor Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!