Association of abdominal obesity with lumbar disc degeneration--a magnetic resonance imaging study

To evaluate whether midsagittal (abdominal) obesity in magnetic resonance imaging (MRI), waist circumference (WC) and body fat percentage are associated with lumbar disc degeneration in early adulthood. We obtained the lumbar MRI (1.5-T scanner) of 325 females and 233 males at a mean age of 21 years...

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Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e56244-e56244
Main Authors: Takatalo, Jani, Karppinen, Jaro, Taimela, Simo, Niinimäki, Jaakko, Laitinen, Jaana, Sequeiros, Roberto Blanco, Samartzis, Dino, Korpelainen, Raija, Näyhä, Simo, Remes, Jouko, Tervonen, Osmo
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Advertising executives
Analysis of Variance
Atherosclerosis
Biology
Body fat
Body mass index
Confidence intervals
Degeneration
Female
Females
Humans
Intervertebral Disc Degeneration - diagnostic imaging
Intervertebral Disc Degeneration - etiology
Intervertebral discs
Logistic Models
Lumbar Vertebrae - diagnostic imaging
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Males
Medicine
NMR
Nuclear magnetic resonance
Obesity
Obesity, Abdominal - complications
Obesity, Abdominal - diagnostic imaging
Odds Ratio
Physics
Physiological aspects
Radiography
Regression analysis
Resonance
Risk Factors
Sex Factors
Statistical analysis
Teenagers
Waist Circumference
Young Adult
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Summary:To evaluate whether midsagittal (abdominal) obesity in magnetic resonance imaging (MRI), waist circumference (WC) and body fat percentage are associated with lumbar disc degeneration in early adulthood. We obtained the lumbar MRI (1.5-T scanner) of 325 females and 233 males at a mean age of 21 years. Lumbar disc degeneration was evaluated using Pfirrmann classification. We analysed the associations of MRI measures of obesity (abdominal diameter (AD), sagittal diameter (SAD), ventral subcutaneous thickness (VST), and dorsal subcutaneous thickness (DST)), WC and body fat percentage with disc degeneration sum scores using ordinal logistic regression. A total of 155 (48%) females and 147 (63%) males had disc degeneration. AD and SAD were associated with a disc degeneration sum score of ≥3 compared to disc degeneration sum score of 0-2 (OR 1.67; 95% confidence interval (CI) 1.20-2.33 and OR 1.40; 95% CI 1.12-1.75, respectively) among males, but we found no association among females. WC was also associated with disc degeneration among males (OR 1.03 per one cm; 95% CI 1.00-1.05), but not among females. Measures of abdominal obesity in MRI and waist circumference were associated with disc degeneration among 21-year-old males.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0056244