Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial cancer risk: a meta-analysis

Emerging evidence indicates that common functional polymorphisms in the estrogen receptor 1 (ESR1) gene may have an impact on an individual's susceptibility to endometrial cancer, but individually published results are inconclusive. The aim of this meta-analysis is to derive a more precise esti...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e60851-e60851
Main Authors: Zhou, Xin, Gu, Yang, Wang, Ding-Ning, Ni, Sha, Yan, Jun
Format: Article
Language:English
Subjects:
Biology
Cancer
Cancer genetics
Cancer research
Codons
Confidence intervals
Continental Population Groups - genetics
Disease susceptibility
Endometrial cancer
Endometrial Neoplasms - ethnology
Endometrial Neoplasms - genetics
Endometrium
Estrogen
Estrogen Receptor alpha - genetics
Estrogen receptors
Estrogens
Female
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease - genetics
Health aspects
Health risks
Hormone replacement therapy
Humans
Medicine
Meta-analysis
Mutation
Phenols (Class of compounds)
Polymorphism
Polymorphism, Single Nucleotide
Populations
Risk analysis
Risk factors
Risk reduction
Statistical analysis
Uterine cancer
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Summary:Emerging evidence indicates that common functional polymorphisms in the estrogen receptor 1 (ESR1) gene may have an impact on an individual's susceptibility to endometrial cancer, but individually published results are inconclusive. The aim of this meta-analysis is to derive a more precise estimation of the associations between eight polymorphisms in the ESR1 gene and endometrial cancer risk. A literature search of PubMed, Embase, Web of Science and China Biology Medicine (CBM) databases was conducted on publications published before November 1(st), 2012. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using the STATA 12.0 software. Thirteen case-control studies were included with a total of 7,649 endometrial cancer cases and 16,855 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results indicated that PvuII (C>T) polymorphism was associated with an increased risk of endometrial cancer, especially among Caucasian populations. There were also significant associations between rs3020314 (C>T) polymorphism and an increased risk of endometrial cancer. Furthermore, rs2234670 (S/L) polymorphism may decrease the risk of endometrial cancer. However, no statistically significant associations were found in XbaI (A>G), Codon 325 (C>G), Codon 243 (C>T), VNTR (S/L) and rs2046210 (G>A) polymorphisms. The current meta-analysis suggests that PvuII (C>T) and rs3020314 (C>T) polymorphisms may be risk factors for endometrial cancer, especially among Caucasian populations.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0060851